2,8-Dichloro-octanoic acid | 17687-55-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,8-Dichloro-octanoic acid
• 英文别名: 2,8-Dichlorooctanoic acid
• CAS: 17687-55-7
• 化学式: C₈H₁₄Cl₂O₂
• 分子量: 213.104
• InChiKey: PGNFDRYTMRTDHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Method of preparing R-(+)-alpha-lipoic acid and its salt
  申请人：Chen Xin

  公开号：US20070015926A1

  公开（公告）日：2007-01-18

  The present invention discloses a method for preparing R-(+)-LA as well as its metal salts including sodium salt, potassium salt, calcium salt, magnesium salt, zinc salt, ferric salt, cooper salt , lithium salt and its organic salt, wherein a racemic Ethyl 6, 8-Dichlorooctanoic acid is employed as starting agents, followed by a hydrolysis and resolution processes to obtain (+)DCA, and then through sulfuration and cyclization process to obtain R-(+)-LA as well as its varied salts. A method for converting the (−)DCA to (+)DCA is also introduced.

  本发明公开了一种制备R-(+)-LA以及其金属盐，包括钠盐、钾盐、钙盐、镁盐、锌盐、铁盐、铜盐、锂盐和其有机盐的方法。该方法使用外消旋乙基6,8-二氯辛酸作为起始剂，经过水解和分离过程得到（+）DCA，然后通过硫化和环化过程得到R-(+)-LA及其各种盐。还介绍了一种将（-）DCA转化为（+）DCA的方法。
• PROCESS FOR THE PRODUCTION OF DIHYDROLIPOIC ACID
  申请人：ALZCHEM TROSTBERG GMBH

  公开号：US20190276396A1

  公开（公告）日：2019-09-12

  The present invention relates to a multi-step process for the production of dihydrolipoic acid, which can particularly be carried out as a one-pot reaction and without isolation of intermediates.

  本发明涉及一种用于生产二硫辛酸的多步过程，可以作为一锅法进行，而无需分离中间体。