2-(2',4',6'-Trifluorophenoxy)propane | 1310416-65-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2',4',6'-Trifluorophenoxy)propane
• 英文别名: 1,3,5-trifluoro-2-propan-2-yloxybenzene
• CAS: 1310416-65-9
• 化学式: C₉H₉F₃O
• 分子量: 190.16
• InChiKey: JINRVWMIXBBCLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF<br/>[FR] BENZOFURANYLES ET BENZOXAZOLYLES SUBSTITUÉS ET LEURS UTILISATIONS
  申请人：KARYOPHARM THERAPEUTICS INC

  公开号：WO2017117406A1

  公开（公告）日：2017-07-06

  The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (I) or (II), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

  该发明通常涉及取代苯并呋喃基和取代苯并噁唑基化合物，更具体地涉及由结构式(I)或(II)表示的化合物，或其药学上可接受的盐，其中变量如本文所定义和描述。该发明还包括合成和使用结构式A的化合物，或其药学上可接受的盐或组合物，例如在治疗癌症（如外套细胞淋巴瘤）和其他疾病和紊乱方面。
• [EN] METHOD FOR PREPARING CONJUGATE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN CONJUGUÉ<br/>[ZH] 制备偶联物的方法
  申请人：SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD

  公开号：WO2019149116A1

  公开（公告）日：2019-08-08

  制备靶向药物-生物活性分子偶联物的方法，由所述方法制备得到的产品以及该产品在预防和/或治疗与细胞活性异常相关的增殖性疾病（包括但不限于癌症疾病）中的用途。
• MULTIFUNCTIONAL ANTIBODY CONJUGATES
  申请人：Bhat Abhijit Suresh

  公开号：US20120201809A1

  公开（公告）日：2012-08-09

  The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising K 188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K 188 , Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.
• SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF
  申请人：Karyopharm Therapeutics Inc.

  公开号：US20190002448A1

  公开（公告）日：2019-01-03

  The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (I) or (II), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.