2-(1-cyanocyclopropane-1-yl)pyridine-5-boronic acid | 827628-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(1-cyanocyclopropane-1-yl)pyridine-5-boronic acid
• 英文别名: 2-(1-cyanocyclopropan-1-yl)pyridine-5-boronic acid；(6-(1-Cyanocyclopropyl)pyridin-3-yl)boronic acid；[6-(1-cyanocyclopropyl)pyridin-3-yl]boronic acid
• CAS: 827628-23-9
• 化学式: C₉H₉BN₂O₂
• 分子量: 187.994
• InChiKey: RRINVYHNXDCGBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.68
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(5-溴吡啶-2-基)环丙烷甲腈 、 联硼酸频那醇酯 在 tris-(dibenzylideneacetone)dipalladium(0) 、 三己基膦 、 potassium acetate 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-(1-cyanocyclopropane-1-yl)pyridine-5-boronic acid
  参考文献：
  名称：

  [EN] CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYLPYRIDINE DERIVATIVES
  [FR] DÉRIVÉS D'ÉTHYLSULFONYLPYRIDINE À SUBSTITUTION CYCLOPROPYLE- (HÉTÉRO)ARYLE

  摘要：

  The present invention relates to cyclopropyl-(hetero)aryl substituted ethylsulphonyl-pyridine derivatives of formula (I),wherein the variables are as defined in the description and in the claims, which can be used as antiparasitic agents for the treatment, prevention and/or control of parasitic infections and/or infestations in animals.

  公开号：

  WO2023036934A1

文献信息

• [EN] CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYLPYRIDINE DERIVATIVES<br/>[FR] DÉRIVÉS D'ÉTHYLSULFONYLPYRIDINE À SUBSTITUTION CYCLOPROPYLE- (HÉTÉRO)ARYLE
  申请人：[en]BOEHRINGER INGELHEIM VETMEDICA GMBH

  公开号：WO2023036934A1

  公开（公告）日：2023-03-16

  The present invention relates to cyclopropyl-(hetero)aryl substituted ethylsulphonyl-pyridine derivatives of formula (I),wherein the variables are as defined in the description and in the claims, which can be used as antiparasitic agents for the treatment, prevention and/or control of parasitic infections and/or infestations in animals.