4-chloro-pent-3-enoic acid ethyl ester | 32886-94-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-chloro-pent-3-enoic acid ethyl ester
• 英文别名: 4-Chlor-pent-3-ensaeure-aethylester；Ethyl-4-chlor-3-pentenoat；ethyl (E)-4-chloropent-3-enoate
• CAS: 32886-94-5
• 化学式: C₇H₁₁ClO₂
• 分子量: 162.616
• InChiKey: CBRMBDBTFFFIJM-GQCTYLIASA-N

物化性质

• 沸点：
  202.7±23.0 °C(Predicted)
• 密度：
  1.067±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chloro-pent-3-enoic acid ethyl ester 、 甲基碘化镁 生成 (E)-5-chloro-2-methylhex-4-en-2-ol
  参考文献：
  名称：

  ELLIOTT, M.;JANES, N. F.;PULMAN, D. A.

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酰丙酸乙酯 生成 4-chloro-pent-3-enoic acid ethyl ester
  参考文献：
  名称：

  ELLIOTT, M.;JANES, N. F.;PULMAN, D. A.

  摘要：

  DOI：

文献信息

• Organic syntheses by means of noble metal compounds—XLVI
  作者：S. Hosaka、J. Tsuji

  DOI：10.1016/s0040-4020(01)98243-2

  日期：1971.1

  Palladium catalysed carbonylation in alcohol of butadiene, isoprene, piperylene and chloroprene has been studied. 3-Pentenoate was obtained from butadiene and similarly 4-methyl-3-pentenoate from isoprene, 2-methyl-3-pentenoate from piperylene and 4-chloro-3-pentenoate from chloroprene were obtained with high selectivity.

  研究了钯催化丁二烯，异戊二烯，间戊二烯和氯丁二烯在醇中的羰基化反应。从丁二烯获得3-戊烯酸酯，类似地从异戊二烯获得4-戊烯酸酯，从戊间二烯获得2-甲基-3-戊烯酸酯，从氯丁二烯获得4-氯-3-戊烯酸酯。
• Effects of Tower Climbing Exercise on Bone Mass, Strength, and Turnover in Growing Rats
  作者：Takuya Notomi、Nobukazu Okimoto、Yuichi Okazaki、Yuri Tanaka、Toshitaka Nakamura、Masashige Suzuki

  DOI：10.1359/jbmr.2001.16.1.166

  日期：——

  To determine the effects of tower climbing exercise on mass, strength, and local turnover of bone, 50 Sprague‐Dawley rats, 10 weeks of age, were assigned to five groups: a baseline control and two groups of sedentary and exercise rats. Rats voluntarily climbed the 200‐cm tower to drink water from the bottle set at the top of it. In 4 weeks, the trabecular bone formation rate (BFR/bone surface [BS]), bone volume (BV/TV), and trabecular thickness (Tb.Th) of both the lumbar vertebra and tibia and the bone mineral density (BMD) of the tibia increased, while the osteoclast surface (Oc.S) decreased. The parameter values in the midfemur, such as the total cross‐sectional area, the moment of inertia, the periosteal mineralizing surface (MS/BS), mineral apposition rate (MAR), BFR/BS, and bending load increased, while the endosteal MAR decreased. In 8 weeks, the increases in the bone mineral content (BMC), BMD of the femur and tibia, and the bending load values of the femur were significant, but the climbing exercise did not increase BMC, BMD, or the compression load of the lumbar vertebra. Although the periosteal MS/BS, MAR, and BFR/BS increased, the endosteal MS/BS, MAR, and BFR/BS decreased. These results show that climbing exercise has a beneficial effect on the femoral cortex and tibia trabecular, rather than the vertebral trabecular. In the midfemur, effects on bone formation are site specific, supporting accelerated cortical drift by mechanical stimulation.

  为了确定爬塔运动对骨骼质量、强度和局部周转的影响，我们将 50 只 10 周大的 Sprague-Dawley 大鼠分为五组：一组为基线对照组，两组分别为静坐组和运动组。大鼠自愿爬上 200 厘米高的塔，从塔顶的瓶子里喝水。4周后，腰椎和胫骨的骨小梁形成率（BFR/骨表面[BS]）、骨量（BV/TV）和骨小梁厚度（Tb.Th）以及胫骨的骨矿物质密度（BMD）均有所增加，而破骨细胞表面（Oc.S）则有所减少。中腓骨的参数值，如总横截面积、惯性矩、骨膜矿化面（MS/BS）、矿物质附着率（MAR）、BFR/BS 和弯曲负荷都有所增加，而骨膜矿化面（MAR）则有所减少。8 周后，股骨和胫骨的骨矿物质含量（BMC）、BMD 以及股骨的弯曲负荷值均显著增加，但攀爬运动并未增加腰椎的骨矿物质含量、BMD 或压缩负荷。虽然骨膜MS/BS、MAR和BFR/BS有所增加，但骨膜内MS/BS、MAR和BFR/BS却有所减少。这些结果表明，爬山运动对股骨皮质和胫骨小梁而非椎骨小梁有益处。在股骨中段，对骨形成的影响具有部位特异性，支持机械刺激加速皮质漂移。
• Julia; Fetizon, Bulletin de la Societe Chimique de France, 1959, p. 1378
  作者：Julia、Fetizon

  DOI：——

  日期：——
• Dihalogen butenes and process for their preparation
  申请人：DU PONT

  公开号：US02102611A1

  公开（公告）日：1937-12-21
• Production of levulinic and homologous acids and intermediate compounds from dihalogen butenes
  申请人：DU PONT

  公开号：US02192298A1

  公开（公告）日：1940-03-05