4-Methyl-N-[2-methyl-5-(1-methyl-1H-pyrrol-2-yl)phenyl]benzenesulfonamide | 1233950-29-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-Methyl-N-[2-methyl-5-(1-methyl-1H-pyrrol-2-yl)phenyl]benzenesulfonamide
• 英文别名: 4-methyl-N-[2-methyl-5-(1-methylpyrrol-2-yl)phenyl]benzenesulfonamide
• CAS: 1233950-29-2
• 化学式: C₁₉H₂₀N₂O₂S
• 分子量: 340.4
• InChiKey: RZFZGAUXAGKWMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  59.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• TOLUIDINE SULFONAMIDES AND THEIR USE
  申请人：Alonson Jorge

  公开号：US20120095024A1

  公开（公告）日：2012-04-19

  The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I).