N-(2-(2-(2-ethoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide | 1191911-22-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-(2-(2-(2-ethoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide
• 英文别名: N-[2-[[2-(2-ethoxy-4-morpholin-4-ylanilino)-5-fluoropyrimidin-4-yl]amino]phenyl]methanesulfonamide
• CAS: 1191911-22-4
• 化学式: C₂₃H₂₇FN₆O₄S
• 分子量: 502.57
• InChiKey: AUPQCDZQEXHWDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• [EN] USE OF LRRK2 INHIBITORS FOR NEURODEGENERATIVE DISEASES<br/>[FR] UTILISATION D'INHIBITEURS DE LRRK2 POUR MALADIES NEURODÉGÉNÉRATIVES
  申请人：CELLZOME LTD

  公开号：WO2009127642A2

  公开（公告）日：2009-10-22

  The invention relates to compounds of formula (I), wherein R1 to R9 and R4a have the meaning as cited in the description and the claims for use in a for use in a method of treating or preventing diseases and disorders associated with LRRK2. Said compounds are useful as inhibitors of LRRK2 for the treatment or prophylaxis of neurodegenerative diseases, like Parkinson's disease or Alzheimer's disease. The invention also relates to the preparation of such compounds.