5-chloro-6-((8-fluoro-1,4-dioxaspiro[4.5]decan-8-yl)methoxy)pyridine-3-sulfonamide | 1256545-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-chloro-6-((8-fluoro-1,4-dioxaspiro[4.5]decan-8-yl)methoxy)pyridine-3-sulfonamide
• 英文别名: 5-chloro-6-[(8-fluoro-1,4-dioxaspiro[4.5]decan-8-yl)methoxy]pyridine-3-sulfonamide
• CAS: 1256545-98-8
• 化学式: C₁₄H₁₈ClFN₂O₅S
• 分子量: 380.825
• InChiKey: DOFOKDXXGLLHDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  5-chloro-6-((8-fluoro-1,4-dioxaspiro[4.5]decan-8-yl)methoxy)pyridine-3-sulfonamide 在 对甲苯磺酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 5-chloro-6-((1-fluoro-4-oxocyclohexyl)methoxy)pyridine-3-sulfonamide
  参考文献：
  名称：

  [EN] 1,3,4,7-TETRAHYDRO-2H-PYRROLO [3',2':5,6] PYRIDO[2,3-B] [1,4] OXAZEPINE BC1-2 INHIBITORS
  [FR] INHIBITEURS DE BCL-2 DE TYPE 1,3,4,7-TÉTRAHYDRO-2H-PYRROLO[3',2':5,6]PYRIDO[2,3-B][1,4]OXAZÉPINE

  摘要：

  The present invention provides for compounds of Formula (I) wherein A, L, W, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL, SLL, and/or ALL.

  公开号：

  WO2023141536A1
• 作为产物：
  描述：

  5,6-二氯-3-吡啶磺酰胺 、 (8-氟-1,4-二氧杂螺[4.5]癸烷-8-基)甲醇 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 生成 5-chloro-6-((8-fluoro-1,4-dioxaspiro[4.5]decan-8-yl)methoxy)pyridine-3-sulfonamide
  参考文献：
  名称：

  [EN] 1,3,4,7-TETRAHYDRO-2H-PYRROLO [3',2':5,6] PYRIDO[2,3-B] [1,4] OXAZEPINE BC1-2 INHIBITORS
  [FR] INHIBITEURS DE BCL-2 DE TYPE 1,3,4,7-TÉTRAHYDRO-2H-PYRROLO[3',2':5,6]PYRIDO[2,3-B][1,4]OXAZÉPINE

  摘要：

  The present invention provides for compounds of Formula (I) wherein A, L, W, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL, SLL, and/or ALL.

  公开号：

  WO2023141536A1

文献信息

• Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
  申请人：Doherty George A.

  公开号：US08557983B2

  公开（公告）日：2013-10-15

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

  本发明涉及抑制抗凋亡Bcl-2蛋白活性的化合物，包含该化合物的组合物以及治疗在其中表达抗凋亡Bcl-2蛋白的疾病的方法。
• Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
  申请人：AbbVie Inc.

  公开号：US09045420B2

  公开（公告）日：2015-06-02

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

  本发明涉及抑制抗凋亡蛋白Bcl-2或Bcl-xL活性的化合物、含有该化合物的组合物及治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
• BCL-2 SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES
  申请人：ABBVIE INC.

  公开号：US20130296295A1

  公开（公告）日：2013-11-07

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

  本发明涉及一种抑制抗凋亡Bcl-2或Bcl-xL蛋白活性的化合物，包含该化合物的组合物以及治疗表达抗凋亡Bcl-2蛋白疾病的方法。
• BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
  申请人：Bruncko Milan

  公开号：US08586754B2

  公开（公告）日：2013-11-19

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

  本发明涉及抑制抗凋亡Bcl-2或Bcl-xL蛋白活性的化合物，含有该化合物的组合物以及治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
• BCL-2 selective apoptosis-inducing agents for the treatment of cancer and immune diseases
  申请人：AbbVie Inc.

  公开号：US09073855B2

  公开（公告）日：2015-07-07

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

  本发明涉及一种抑制抗凋亡Bcl-2或Bcl-xL蛋白活性的化合物，包含这些化合物的组合物以及治疗在其中表达抗凋亡Bcl-2蛋白的疾病的方法。