4-tert-butyl-N-(4-chloro-2-(5-methyl-4-(morpholinomethyl)-1H-1,2,3-triazol-1-yl)phenyl)benzenesulfonamide | 1094759-58-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-tert-butyl-N-(4-chloro-2-(5-methyl-4-(morpholinomethyl)-1H-1,2,3-triazol-1-yl)phenyl)benzenesulfonamide
• 英文别名: 4-tert-butyl-N-[4-chloro-2-[5-methyl-4-(morpholin-4-ylmethyl)triazol-1-yl]phenyl]benzenesulfonamide
• CAS: 1094759-58-6
• 化学式: C₂₄H₃₀ClN₅O₃S
• 分子量: 504.053
• InChiKey: UHCJIRXBSDJBPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  97.7
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• N-(2-(HETARYL)ARYL) ARYLSULFONAMIDES AND N-(2-(HETARYL) HETARYL ARYLSULFONAMIDES
  申请人：Charvat Trevor T.

  公开号：US20090005410A1

  公开（公告）日：2009-01-01

  Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

  提供了作为CCR9受体强效拮抗剂的化合物。动物实验表明，这些化合物对于治疗炎症非常有效，而炎症是CCR9的典型疾病特征。这些化合物通常是芳基磺酰胺衍生物，可用于制药组合物、治疗CCR9介导疾病的方法，以及作为鉴定CCR9拮抗剂的检测中的对照物。
• N-(2-(HETARYL)ARYL)ARYLSULFONAMIDES AND N-(2-(HETARYL)HETARYL ARYLSULFONAMIDES
  申请人：Charvat Trevor T.

  公开号：US20120245138A1

  公开（公告）日：2012-09-27

  Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

  提供了作为CCR9受体的有效拮抗剂的化合物。动物实验表明这些化合物对于治疗CCR9标志性疾病炎症是有用的。这些化合物通常是芳基磺酰胺衍生物，可用于制药组合物、治疗CCR9介导的疾病的方法，以及作为鉴定CCR9拮抗剂的试验控制。
• N-(2-(HETARYL)ARYL) ARYLSULFONAMIDES AND N-(2-(HETARYL)HETARYL ARYLSULFONAMIDES
  申请人：Charvat Trevor T.

  公开号：US20100331302A1

  公开（公告）日：2010-12-30

  Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

  提供了一些化合物，它们作为CCR9受体的有效拮抗剂。动物实验表明，这些化合物对于治疗CCR9标志性疾病炎症非常有用。这些化合物通常是芳基磺酰胺衍生物，并且在制药组合物、治疗CCR9介导疾病的方法以及用于识别CCR9拮抗剂的测定中作为对照物质非常有用。
• N-(2-(HETARYL)ARYL)ARYLSULFONAMIDES AND N-(2-(HETARYL)HETARYL)ARYLSULFONAMIDES
  申请人：ChemoCentryx, Inc.

  公开号：EP2170823B1

  公开（公告）日：2014-08-06
• US7776877B2
  申请人：——

  公开号：US7776877B2

  公开（公告）日：2010-08-17