(R)-tert-butyl 2-acetoxy-2-((R)-3-oxo-4-(6-(trifluoromethyl)pyridin-2-yl)morpholin-2-yl)acetate | 1269521-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (R)-tert-butyl 2-acetoxy-2-((R)-3-oxo-4-(6-(trifluoromethyl)pyridin-2-yl)morpholin-2-yl)acetate
• 英文别名: tert-butyl (2R)-2-acetyloxy-2-[(2R)-3-oxo-4-[6-(trifluoromethyl)pyridin-2-yl]morpholin-2-yl]acetate
• CAS: 1269521-07-4
• 化学式: C₁₈H₂₁F₃N₂O₆
• 分子量: 418.37
• InChiKey: BMSOBPZCWLZHDB-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  95
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS
  申请人：CHACKALAMANNIL Samuel

  公开号：US20110135650A1

  公开（公告）日：2011-06-09

  The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

  本发明提供了公式（I）所述的化合物，或其药学上可接受的盐或溶剂。本发明还提供了包含一种或多种所述化合物的药物组合物，并且提供了使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化变化的方法。
• US8987242B2
  申请人：——

  公开号：US8987242B2

  公开（公告）日：2015-03-24
• [EN] MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS<br/>[FR] COMPOSÉS MORPHOLINONES COMME INHIBITEURS DU FACTEUR IXA
  申请人：MOCHIDA PHARM CO LTD

  公开号：WO2011025565A1

  公开（公告）日：2011-03-03

  The present invention provides compounds having the formula (I) or a pharmaceutically acceptable salt or a solvate thereof, pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.