| 1198398-18-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• CAS: 1198398-18-3
• 化学式: C₃₃H₃₄ClF₂NO₄SSi
• 分子量: 642.239
• InChiKey: UQLZKPHAIJLLJD-NSJVFKKDSA-N

反应信息

• 作为反应物：
  描述：

  在 四丁基氟化铵 作用下， 生成 [(3S,5R)-4-(4-chlorophenyl)sulfonyl-5-(3,5-difluorophenyl)morpholin-3-yl]methanol
  参考文献：
  名称：

  Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability

  摘要：

  A new class of 2,6-disubstituted morpholine N-arylsulfonamide gamma-secretase inhibitors was designed based on the introduction of a morpholine core in lieu or piperidine in our lead series. This resulted in compounds with improved CYP 3A4 profiles. Several analogs that were active at lowering Ab levels in Tg CRND8 mice upon oral administration were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.055
• 作为产物：
  描述：

  在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 生成
  参考文献：
  名称：

  Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability

  摘要：

  A new class of 2,6-disubstituted morpholine N-arylsulfonamide gamma-secretase inhibitors was designed based on the introduction of a morpholine core in lieu or piperidine in our lead series. This resulted in compounds with improved CYP 3A4 profiles. Several analogs that were active at lowering Ab levels in Tg CRND8 mice upon oral administration were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.055