threo-3,4-Dihydroxy-1-octin | 62692-16-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: threo-3,4-Dihydroxy-1-octin
• 英文别名: d,l-threo-3,4-dihydroxy-1-octyne；threo-3,4-dihydroxy-1-octyne；Oct-1-yne-3,4-diol
• CAS: 62692-16-4
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: DOFYKPFETMIFJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  d,l-erythro-3-Hydroxy-4-acetyloxy-1-trimethylsilyl-1-octin 在 氢氧化钾 作用下， 以 甲醇 、 水 为溶剂， 生成 threo-3,4-Dihydroxy-1-octin
  参考文献：
  名称：

  11-(2-Hydroxyethylthio)prostenoic acid E.sub.2 series derivatives

  摘要：

  本披露涉及某些11-(2-羟乙基硫基)-9-酮-前列腺素酸E系列衍生物及其中间体，可用作支气管扩张剂和炎症介质释放抑制剂。

  公开号：

  US04085272A1

文献信息

• 1-Substituted-1-oxo-prostane-derivatives of the E, A and F series
  申请人：American Cyanamid Company

  公开号：US04297516A1

  公开（公告）日：1981-10-27

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: ##STR1## wherein R is C.sub.1 to C.sub.6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR.sub.16, SR.sub.16, F, or Cl, and R.sub.16 is C.sub.1 to C.sub.6 alkyl.

  本发明公开的药物活性前列腺素衍生物属于E、F或A系列，在α链的末端亚甲基碳上有一个取代基，该取代基从以下组中选择：##STR1## 其中R是C.sub.1至C.sub.6烷基，和苯基或苯基，苯基上带有1个或多个取代基，该取代基从以下组中选择：C.sub.1-C.sub.4烷基，OR.sub.16，SR.sub.16，F或Cl，R.sub.16是C.sub.1至C.sub.6烷基。
• 15,16-Dioxy prostenoic acids and esters and intermediates in their
  申请人：American Cyanamid Company

  公开号：US04111959A1

  公开（公告）日：1978-09-05

  This disclosure describes novel 15,16-dioxy prostenoic acids and esters useful as bronchodilators, anti-inflammatory agents, hypotensives and gastric acid secretion inhibitors.

  这份披露描述了作为支气管扩张剂、抗炎药物、降压剂和胃酸分泌抑制剂有用的新型15,16-二氧基前列腺酸和酯。
• 1-Hydroxymethyl-1-1-oxo prostane derivatives of the E and F series
  申请人：American Cyanamid Company

  公开号：US04254285A1

  公开（公告）日：1981-03-03

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, di-C.sub.1 -C.sub.4 -alkylamino, and phenyl orphenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物：##STR1## 其中R是烷基基团，R.sub.15是C.sub.1 -C.sub.4烷基，C.sub.1 -C.sub.4烷氧基，二C.sub.1 -C.sub.4-烷基氨基，以及苯基或苯基取代物，所述苯基或苯基取代物中取代基选择自C.sub.1 -C.sub.4烷基，OR，SR，F或Cl的组成，其中R如前所定义。
• 1-Hydroxymethyl-1-oxo-prostane derivatives of the E.sub.2 series
  申请人：American Cyanamid Company

  公开号：US04170597A1

  公开（公告）日：1979-10-09

  Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the E.sub.2 series.

  拥有E.sub.2系列中1-(羟甲基)-1-氧代-前列酮结构的前列酮的衍生物、类似物和同系物。
• Vinylstannyl derivatives
  申请人：American Cyanamid Company

  公开号：US04477388A1

  公开（公告）日：1984-10-16

  Vinylstannyl derivatives and the processes for their conversion to vinyliodides, vinylbromides and vinyllithium reagents. The vinylstannyl, vinyliodides, vinylbromide derivatives and vinyllithiums are useful as intermediates for the preparation of prostaglandin analogs.

  乙烯基锡衍生物及其转化为乙烯碘化物、乙烯溴化物和乙烯锂试剂的过程。乙烯基锡、乙烯碘化物、乙烯溴化物衍生物和乙烯锂试剂可用作合成前列腺素类似物的中间体。