5'-chloro-3-(3-chlorophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione | 131141-20-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5'-chloro-3-(3-chlorophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
• CAS: 131141-20-3
• 化学式: C₁₆H₁₀Cl₂N₂O₂S
• 分子量: 365.24
• InChiKey: ZCYPSILYJNITGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氯苯胺 以 甲苯 为溶剂， 反应 5.0h， 生成 5'-chloro-3-(3-chlorophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
  参考文献：
  名称：

  Joshi; Dandia; Bhagat, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 8, p. 766 - 770

  摘要：

  DOI：

文献信息

• IMPROVED ONE-POT SYNTHESIS OF 3-SPIRO INDOLINES UNDER MICROWAVE IRRADIATION
  作者：Anshu Dandia、Mitali Saha、Harshita Taneja

  DOI：10.1080/10426509808035679

  日期：1998.8.1

  The potential of the domestic microwave oven has been utilized to accelerate the one-pot synthesis of spiro[indole-thiazolidine]diones and spiro[indole-benzothiazine]diones by condensation of substituted indole-2,3-diones (1) and appropriate anilines (2) with mercaptopropionic acid (4a/b) and o-mercaptobenzoic acid (5) in open borosilicate vessels, using ethanol as energy transfer medium. The reaction rate was 400-500 times faster than the reaction rate in the conventional way. Excellent isolated yields with easier workup than classical heating were the main advantages observed.