Isopropenyl-(4-methoxy-phenyl)-amine | 36321-07-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Isopropenyl-(4-methoxy-phenyl)-amine
• 英文别名: 4-methoxy-N-prop-1-en-2-ylaniline
• CAS: 36321-07-0
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: SCEGVIVWKYMWBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。
• PHARMACEUTICAL COMPOUNDS
  申请人：NicOx S.A.

  公开号：EP1169294B1

  公开（公告）日：2007-12-05
• [EN] COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS<br/>[FR] COMPOSÉS ET PROCÉDÉS D'AMÉLIORATION D'UNE FIBRINOLYSE ENDOGÈNE DYSFONCTIONNELLE À L'AIDE D'INHIBITEURS D'HISTONE DÉSACÉTYLASE
  申请人：LARSSON PIA

  公开号：WO2012120262A1

  公开（公告）日：2012-09-13

  There is provided a compound which is a histone deacetylase (HDAC) inhibitor, or a pharmaceutically acceptable ester, amide, solvate or salt thereof, for use in: (I) treating or preventing a pathological condition associated with excess fibrin deposition and/or thrombus formation; and/or (II) potentiating the degradation of fibrin deposits and preventing such deposits associated with pathological conditions or which may lead to such conditions, wherein the HDAC inhibitor, and the dose thereof, is as described in the description. There is also provided valproic acid, or a pharmaceutically acceptable salt thereof, for use in improving or normalizing endogenous fibrinolysis impaired by local or systemic inflammation.