ethyl 3',4'-dihydro-8H-spiro[8-azabicyclo[3.2.1]octane-3,1'-isochromene]-8-carboxylate | 917242-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: ethyl 3',4'-dihydro-8H-spiro[8-azabicyclo[3.2.1]octane-3,1'-isochromene]-8-carboxylate
• 英文别名: ethyl 3',4'-dihydrospiro[8-azabicyclo[3.2.1]octane-3,1'-isochromene]carboxylate；Ethyl spiro[3,4-dihydroisochromene-1,3'-8-azabicyclo[3.2.1]octane]-8'-carboxylate
• CAS: 917242-93-4
• 化学式: C₁₈H₂₃NO₃
• 分子量: 301.386
• InChiKey: WMABUEDZROXWSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Alpha-(Aryl-or Heteroaryl-Methyl)-Beta-Piperidino Propanamide Compounds as Orl-1-Receptor Antagonists
  申请人：Hashizume Yoshinobu

  公开号：US20080200490A1

  公开（公告）日：2008-08-21

  This invention provides the compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 independently represent hydrogen or the like; R 3 and R 4 independently represents hydrogen or the like; R 5 represents aryl or the like; —X—Y— represents —CH 2 O— or the like; and n represents 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.

  本发明提供了式（I）的化合物或其药学上可接受的盐，其中R1和R2独立地代表氢或类似物；R3和R4独立地代表氢或类似物；R5代表芳基或类似物；—X—Y—代表—CH2O—或类似物；n代表0、1或2。这些化合物具有ORL1受体拮抗活性；因此，它们可用于治疗疾病或情况，如疼痛、各种中枢神经系统疾病等。
• Alpha-(Aryl-or Heteroaryl-Methyl)-Beta-Piperidinopropanoic Acid Compounds as Orl-1-Receptor Antagonists
  申请人：Hashizume Yoshinobu

  公开号：US20080207665A1

  公开（公告）日：2008-08-28

  This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester or salt thereof, wherein R 1 and R 2 independently represent hydrogen or the like; R 3 represents aryl or the like; —X—Y— represents —CH 2 O— or the like, and n represents 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.

  本发明提供了以下化合物的配方(I)：或其药学上可接受的酯或盐，其中R1和R2独立地代表氢或类似物；R3代表芳基或类似物；-X-Y-代表-CH2O-或类似物，n代表0、1或2。这些化合物具有ORL1受体拮抗活性；因此，它们可用于治疗疼痛、各种中枢神经系统疾病等疾病或病况。
• ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS
  申请人：Pfizer, Inc.

  公开号：EP1893610A2

  公开（公告）日：2008-03-05
• [EN] ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS<br/>[FR] COMPOSES ALPHA-(ARYL-OU HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE UTILES EN TANT QU'ANTAGONISTES DU RECEPTEUR ORL1
  申请人：PFIZER JAPAN INC

  公开号：WO2006134486A2

  公开（公告）日：2006-12-21

  [EN] This invention provides the compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R¹ and R² independently represent hydrogen or the like; R³ and R⁴ independently represents hydrogen or the like; R⁵ represents aryl or the like; -X-Y- represents -CH₂O- or the like; and n represents 0, 1 or 2.These compounds have ORL1 -receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
  [FR] La présente invention concerne les composés représentés par la formule (I) ou un sel pharmaceutiquement acceptable de ces derniers. Dans la formule, R¹ et R² représentent indépendamment hydrogène ou similaire; R³ et R⁴ représentent indépendamment hydrogène ou similaire; R⁵ représente aryle ou similaire; -X-Y- représente -CH₂O- ou similaire; et n représente 0, 1 ou 2. Ces composés présentent une activité antagoniste du récepteur ORL1 et sont donc utiles pour traiter les maladies ou les pathologies telles que la douleur, diverses maladies du système nerveux central et autres. Formule (I)