5-(aminomethyl)isophthalic acid | 1415325-74-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(aminomethyl)isophthalic acid
• 英文别名: 5-(Aminomethyl)benzene-1,3-dicarboxylic acid
• CAS: 1415325-74-4
• 化学式: C₉H₉NO₄
• 分子量: 195.175
• InChiKey: JTEQMZRMFBQNKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  dimethyl 5-(azidomethyl)isophthalate 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 8.0h， 以0.36 g的产率得到5-(aminomethyl)isophthalic acid
  参考文献：
  名称：

  Introduction of Functionalized Mesopores to Metal–Organic Frameworks via Metal–Ligand–Fragment Coassembly

  摘要：

  Introduction of functionalized mesopores into microporous metal-organic frameworks (MOFs) can endow them with suitable properties for applications in gas storage, separation, catalysis, and drug delivery. However, common methods for functionalization (including pre- and post-synthetic modifications) of the internal surface of a MOF reduce the pore size of the MOF because the additional functional groups fill up the pores. We present a metal-ligand-fragment coassembly strategy for the introduction of (meso)pores functionalized with various substituent groups on the ligand fragments. Astonishingly, this new functionalization strategy increases the pore volume of a MOF instead of reducing it. Since the ligand fragments are often readily available or easily prepared, the new procedure for synthesis of the modified MOFs becomes much easier and more applicable than existing approaches. Remarkably, mesopores can be generated conveniently and controllably by the coassembly of a ligand and its fragment containing the desired functional groups. The fragment/ligand ratio has been optimized to preserve the parent structure and to promote maximum mesopore introduction, which has led to a systematic evaluation of the effectiveness of a series of functional groups for the adsorption of guest molecules.

  DOI：

  10.1021/ja3085884

文献信息

• [EN] AZACYANINE DYES AND USE THEREOF<br/>[FR] COLORANTS D'AZACYANINE ET LEUR UTILISATION
  申请人：ECOLE POLYTECHNIQUE FED LAUSANNE EPFL

  公开号：WO2019180475A1

  公开（公告）日：2019-09-26

  The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

  该应用程序提供荧光染料，这些染料是氰染料，它们在吲哚离子杂环和/或连接它们的亚甲链中包含额外的氮杂基。描述了用于共轭的对称和非对称化学反应性氮杂基染料，以及它们的生物共轭物，用于体外和体内分析和荧光成像。
• AZACYANINE DYES AND USE THEREOF
  申请人：Ecole Polytechnique Fédérale de Lausanne (EPFL)

  公开号：US20180079906A1

  公开（公告）日：2018-03-22

  The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

  该应用程序提供荧光染料，这些染料是氰染料，它们在吲哚啉环中和/或连接它们的亚甲链中包含额外的氮杂基。描述了用于共轭的对称和非对称化学反应性氮杂氰染料，以及它们的生物共轭物用于体外和体内分析和荧光成像。
• BACTERIAL IMAGING AGENTS AND METHODS OF USING SAME
  申请人：VisEn Medical, Inc.

  公开号：US20130309168A1

  公开（公告）日：2013-11-21

  The invention provides a family of agents that target bacterial infection, which can be used as imaging agents or therapeutic agents. The agents can be used to image sites of bacterial infection as well as other physiological processes in a subject.

  本发明提供了一系列针对细菌感染的药物，可用作成像剂或治疗剂。这些药物可用于成像受试者体内的细菌感染部位以及其他生理过程。
• Carbonic Anhydrase Targeting Agents and Methods of Using Same
  申请人：Groves Kevin

  公开号：US20120321563A1

  公开（公告）日：2012-12-20

  The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

  该发明提供了针对碳酸酐酶的药剂，可用作成像药剂或治疗药剂。这些药剂可用于成像肿瘤缺氧以及主体其他的生理过程。
• Carbonic anhydrase targeting agents and methods of using same
  申请人：Groves Kevin

  公开号：US10221159B2

  公开（公告）日：2019-03-05

  The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

  本发明提供靶向碳酸酐酶的制剂，可用作成像剂或治疗剂。这些制剂可用于成像肿瘤缺氧以及受试者的其他生理过程。