| 801270-04-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 801270-04-2
• 化学式: C₈H₁₁N₃O₄S*Cl*Cu*H*H₂O
• 分子量: 363.281
• InChiKey: MZJZVGQVGICMTG-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  copper(II) choride dihydrate 、 Et-H3ct*H2O 以 甲醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Copper(II) Complexes with Substituted Thiosemicarbazones of α-Ketoglutaric Acid:  Synthesis, X-ray Structures, DNA Binding Studies, and Nuclease and Biological Activity

  摘要：

  New a-ketoglutaric acid thiosemicarbazone (H(3)ct) derivatives and their copper complexes were synthesized and characterized by analytical and spectroscopic (IR and NMR) methods. For two of the ligands, Me-H(3)ct and Allyl-H(3)ct, and for a complex, [Cu(Me-Hct)(OH2)](n)(.)2nH(2)O, the X-ray structures were also determined. In the latter the copper atom shows a 4 + 1 pyramidal coordination, a water oxygen appears in the apical position, and three of the basal positions are occupied by the SNO tridentate ligand and the fourth by a carboxylic oxygen of an adjacent molecule that gives rise to a polymeric chain. DNA binding constants were determined, and studies of thermal denaturation profiles and nuclease activity were also performed. Tests in vitro on human leukemia cell line U937 were carried out on cell growth inhibition, cell cycle, and apoptosis induction.

  DOI：

  10.1021/ic049883b