Acetic acid (3R,4S,5S)-2,3,6-tribenzyl-5-((S)-1-bromo-2-phenyl-ethyl)-1,1-dioxo-1λ⁶-[1,2,6]thiadiazinan-4-yl ester | 210635-31-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Acetic acid (3R,4S,5S)-2,3,6-tribenzyl-5-((S)-1-bromo-2-phenyl-ethyl)-1,1-dioxo-1λ⁶-[1,2,6]thiadiazinan-4-yl ester
• 英文别名: [(3R,4S,5S)-2,3,6-tribenzyl-5-[(1S)-1-bromo-2-phenylethyl]-1,1-dioxo-1,2,6-thiadiazinan-4-yl] acetate
• CAS: 210635-31-7
• 化学式: C₃₄H₃₅BrN₂O₄S
• 分子量: 647.633
• InChiKey: IOFOCFUNYBFWEK-YLWZKEKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  42
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  75.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Acetic acid (3R,4S,5S)-2,3,6-tribenzyl-5-((S)-1-bromo-2-phenyl-ethyl)-1,1-dioxo-1λ⁶-[1,2,6]thiadiazinan-4-yl ester 在 锌 作用下， 以 溶剂黄146 为溶剂， 生成 Acetic acid (3R,4R,5R)-2,3,6-tribenzyl-1,1-dioxo-5-phenethyl-1λ⁶-[1,2,6]thiadiazinan-4-yl ester
  参考文献：
  名称：

  Stereospecific, Stereoselective Rearrangement of Hexahydro-1,3-diazepin-2-ones to Tetrahydropyrimidin-2-ones and Imidazolidin-2-ones, a Useful Route for the Synthesis of HIV Protease Inhibitors

  摘要：

  We have discovered that hexahydro-5,6-dihydroxy-1,3-diazepin-2-ones can undergo a stereospecific, stereoselective-rearrangement, ring-contraction reaction to give the corresponding tetrahydro-5-hydroxypyrimidin-2-ones. This reaction is very general and proceeds in excellent yields. The rearrangement proceeds through the formation of the aziridinium cationic intermediate I, which is subsequently opened by nucleophilic attack (S(N)2) at the less hindered carbon to give the rearranged product. The X-ray structure determination of the rearranged product (17a; Figure 1) confirmed the structure and the stereochemical assignments and is consistent with:the proposed mechanism. When the urea nitrogens are not substituted, the aziridine product can be isolated, and its structure (24; Figure 2) was also confirmed by X-ray analysis. The aziridine product can be used as a mono N-protecting group to synthesize differentially disubstituted N,N'-dialkylated tetrahydropyrimidin-2-one analogues. The tetrahydro-5-hydroxypyrimidin-2-ones can further undergo a second stereospecific, stereoselective-rearrangement, ring-contraction reaction to give the corresponding imidazolidinones. This second rearrangement is also very general and proceeds in good yields. These tetrahydro-5-hydroxypyrimidin-2-ones and imidazolidinones have previously been shown to be potent HIVPR inhibitors.

  DOI：

  10.1021/jo980533e
• 作为产物：
  描述：

  2-乙酰氧基异丁酰溴 、 (3R,4S,5S,6R)-2,3,6,7-Tetrabenzyl-1,1-dioxo-1λ⁶-[1,2,7]thiadiazepane-4,5-diol 以 二氯甲烷 为溶剂， 反应 0.17h， 生成 Acetic acid (3R,4S,5S)-2,3,6-tribenzyl-5-((S)-1-bromo-2-phenyl-ethyl)-1,1-dioxo-1λ⁶-[1,2,6]thiadiazinan-4-yl ester 、 Acetic acid (3R,4S,5R,6R)-2,3,6,7-tetrabenzyl-5-bromo-1,1-dioxo-1λ⁶-[1,2,7]thiadiazepan-4-yl ester
  参考文献：
  名称：

  Stereospecific, Stereoselective Rearrangement of Hexahydro-1,3-diazepin-2-ones to Tetrahydropyrimidin-2-ones and Imidazolidin-2-ones, a Useful Route for the Synthesis of HIV Protease Inhibitors

  摘要：

  We have discovered that hexahydro-5,6-dihydroxy-1,3-diazepin-2-ones can undergo a stereospecific, stereoselective-rearrangement, ring-contraction reaction to give the corresponding tetrahydro-5-hydroxypyrimidin-2-ones. This reaction is very general and proceeds in excellent yields. The rearrangement proceeds through the formation of the aziridinium cationic intermediate I, which is subsequently opened by nucleophilic attack (S(N)2) at the less hindered carbon to give the rearranged product. The X-ray structure determination of the rearranged product (17a; Figure 1) confirmed the structure and the stereochemical assignments and is consistent with:the proposed mechanism. When the urea nitrogens are not substituted, the aziridine product can be isolated, and its structure (24; Figure 2) was also confirmed by X-ray analysis. The aziridine product can be used as a mono N-protecting group to synthesize differentially disubstituted N,N'-dialkylated tetrahydropyrimidin-2-one analogues. The tetrahydro-5-hydroxypyrimidin-2-ones can further undergo a second stereospecific, stereoselective-rearrangement, ring-contraction reaction to give the corresponding imidazolidinones. This second rearrangement is also very general and proceeds in good yields. These tetrahydro-5-hydroxypyrimidin-2-ones and imidazolidinones have previously been shown to be potent HIVPR inhibitors.

  DOI：

  10.1021/jo980533e