6-(4-(2-dioxolyl)-phenyl)[5H]pyrrolo[2,3-b]pyrazine | 860024-99-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 6-(4-(2-dioxolyl)-phenyl)[5H]pyrrolo[2,3-b]pyrazine
• 英文别名: 6-[4-(1,3-dioxol-2-yl)phenyl]-5H-pyrrolo[2,3-b]pyrazine
• CAS: 860024-99-3
• 化学式: C₁₅H₁₁N₃O₂
• 分子量: 265.271
• InChiKey: QYVQNAFKQYTJEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  60
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Derivatives of Pyrrolo-Pyrazines Having a Kinase Inhibitory Activity and Their Biological Applications
  申请人：Meijer Laurent

  公开号：US20080161312A1

  公开（公告）日：2008-07-03

  The invention relates to pyrrolo[2,3b]-pyrazine derivatives having the general Formula (I) wherein R2 and R3 are identical or different and represent H, C1-C6 alkyl, said alkyl being a straight or branched-chain alkyl, which can be substituted, R6 is an optionally substituted aromatic cycle Ar or a cycloalkyl, said cycloalkyl being optionally substituted by an aryl group which can also be substituted, R7 is H, C1-C6 alkyl, (alk.)n-hal., CH2—CH═CH2, CH2-cycloalkyl, CH2—Ar, with “alk.” being a C1-C6 alkylene group, n being 1-6, Z is H or CH3. Application as active principle of pharmaceutical compositions, particularly for treating or preventing neurodegenerative disorders and proliferative disorders.
• US8106050B2
  申请人：——

  公开号：US8106050B2

  公开（公告）日：2012-01-31