diethyl 4-(3-methoxyphenyl)-2,6-dimethyl-4H-pyran-3,5-dicarboxylate | 1454931-96-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: diethyl 4-(3-methoxyphenyl)-2,6-dimethyl-4H-pyran-3,5-dicarboxylate
• CAS: 1454931-96-4
• 化学式: C₂₀H₂₄O₆
• 分子量: 360.407
• InChiKey: UGQDHIFEJBRKQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.48
• 重原子数：
  26.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  乙酰乙酸乙酯 、 3-甲氧基苯甲醛 以 乙醇 为溶剂， 反应 0.75h， 以85%的产率得到diethyl 4-(3-methoxyphenyl)-2,6-dimethyl-4H-pyran-3,5-dicarboxylate
  参考文献：
  名称：

  SnCl2/nano SiO2: A green and reusable heterogeneous catalyst for the synthesis of polyfunctionalized 4H-pyrans

  摘要：

  A highly efficient and general method for the synthesis of polyfunctionalized 4H-pyrans is established through a one-pot multicomponent cyclocondensation of aromatic aldehydes with CH acids, malononitrile and ethyl acetoacetate using nano silica supported tin (II) chloride as a catalyst. In this method SnCl2/nano SiO2 was used as green and reusable catalyst. Excellent yields, short reaction times, simple workup, and inexpensiveness and commercially availability of the catalyst are the advantages of this method. (C) 2013 Javad Safaei-Ghomi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.06.021