n-Propylneoheptanoat | 5837-94-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: n-Propylneoheptanoat
• 英文别名: Propyl 2,2-dimethylpentanoate
• CAS: 5837-94-5
• 化学式: C₁₀H₂₀O₂
• 分子量: 172.268
• InChiKey: IJDXQSKVZHXCHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for the production of esters
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0629603A1

  公开（公告）日：1994-12-21

  A process for the production of an ester or a mixture of esters, comprising allowing an olefin, carbon monoxide and an alcohol to react in the presence of hydrogen fluoride. The esters can be produced at high yields at a low temperature over a short period of time. The esters can be easily separated from the reaction solution and hydrogen fluoride can be recycled. The kinetic viscosity and the colouration of the mixture of the esters can be easily adjusted and an increase in the viscosity of the esters can be prevented.

  一种生产酯或酯混合物的工艺，包括让烯烃、一氧化碳和醇在氟化氢存在下发生反应。在低温条件下，可在短时间内生产出高产率的酯。酯可以很容易地从反应溶液中分离出来，氟化氢也可以回收利用。酯类混合物的动力学粘度和颜色可以很容易地调节，并且可以防止酯类粘度的增加。
• HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS
  申请人：Alkermes Pharma Ireland Limited

  公开号：EP2445502B1

  公开（公告）日：2017-06-21
• EP2521711B1
  申请人：——

  公开号：EP2521711B1

  公开（公告）日：2017-08-16
• Segmented Degradable Polymers and Conjugates Made Therefrom
  申请人：McManus Samuel P.

  公开号：US20100010158A1

  公开（公告）日：2010-01-14

  The present invention provides, among other things, segmented, degradable polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains divided or separated by one or more degradable linkages into polymer segments having a molecular weight suitable for renal clearance. The polymeric reagents can have a substantially linear structure, a branched structure, or a multiarm structure. Each structure includes one or more linkages capable of degradation in vivo.
• Hydroxyapatite-Targeting Multiarm Polymers and Conjugates Made Therefrom
  申请人：McManus Samuel P.

  公开号：US20100286355A1

  公开（公告）日：2010-11-11

  The present invention provides hydmoxyapatite-targeting, multiarm polymer reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatile-targeting moieties located at the terminus of one or more of the polymer chains. The multiarm polymers are optionally divided or separated by one or more degradable linkages into polymer segments having a molecular weight suitable for renal clearance. The polymeric reagents of the invention can have a substantially linear structure, although branched or multiarm structures are contemplated as well. The invention is suited for applications in which use of a high molecular weight polymer is desired, such as a total polymer number average molecular weight of at least about 30,000 Da for linear polymers and 20,000 Da for multiarm polymers. Each structure includes one or more linkages capable of degradation in vivo. The use of multiple hydroxyapatite-targeting moieties on each polymer molecule enhances the ability of the polymer reagent to selectively target and bind to hydroxyapatite surfaces, which in turn, can increase the concencentration of biologically active moiety delivered to the bone site.