盐酸莱克多巴胺 | 90274-24-1

• 物质功能分类: 分析化学 - 标准品 - 标准物质
• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 盐酸莱克多巴胺
• 中文别名: 4-[3-[2-羟基-2-(4-羟基苯基)-乙基]氨基丁基]苯酚盐酸盐
• 英文名称: Ractopamine hydrochloride
• 英文别名: 1-(4-hydroxyphenyl)-2-[1-methyl-3-(4-hydroxyphenyl)propylamino]ethanol hydrochloride；[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-[4-(4-hydroxyphenyl)butan-2-yl]azanium;chloride
• CAS: 90274-24-1
• 化学式: C₁₈H₂₃NO₃*ClH
• 分子量: 337.846
• InChiKey: JHGSLSLUFMZUMK-UHFFFAOYSA-N

物化性质

• 熔点：
  165-167 °C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• 稳定性/保质期：

  1. 瘦肉精在医学上称为“盐酸克伦特罗”，它既不是兽药，也不是添加剂，而是肾上腺素类神经兴奋剂，属于β-兴奋剂类激素。其化学成分是α-(叔丁氨基甲基)-4-氨基3,5-二氯苯甲醇盐酸盐。这种物质严重危害畜牧业的健康发展和畜产品安全，可被视为一种毒品。

     盐酸克伦特罗最初仅用于医学急救和肺科病治疗（主要是平喘）。在动物体内，它可以重新分配营养物质，促进动物生长、提高瘦肉率、减少脂肪沉积并提升饲料利用率。

计算性质

• 辛醇/水分配系数(LogP)：
  3.16
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.7
• 氢给体数：
  5
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S24,S26,S37
• 危险类别码：
  R20/22,R43
• 海关编码：
  2922199090
• 储存条件：
  0-6°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Ractopamine HCl
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Ractopamine HCl
CAS number: 90274-24-1

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C18H23NO3.ClH
Molecular weight: 337.8

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

盐酸莱克多巴胺是一种苯乙醇胺β-肾上腺素能激动剂，主要用于将营养物质从脂肪沉积转移到瘦肉沉积。其作用机制主要是通过调节肌肉和脂肪细胞中的代谢途径和信号传导以增强蛋白质积累。此外，它还能调节激素释放并改变血流。研究显示，盐酸莱克多巴胺能够增加啮齿动物和家畜的肌肉质量，并减少体脂含量。

反应信息

• 作为反应物：
  描述：

  盐酸莱克多巴胺 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.5h， 生成 莱克多巴胺
  参考文献：
  名称：

  Use of RR/SR-ractopamine

  摘要：

  本发明公开了一种通过向动物投与RR-拉托巴胺和SR-拉托巴胺混合物的治疗有效量来促进或改善动物的饲料效率和肌肉脂肪比的方法。同时，还公开了制造RR/SR-拉托巴胺的方法。

  公开号：

  US20090143480A1
• 作为产物：
  描述：

  莱克多巴胺 在 盐酸 作用下， 以 水 为溶剂， 生成 盐酸莱克多巴胺
  参考文献：
  名称：

  Methods of Accelerating Muscle Growth, Decreasing Fat Deposits and Improving Feed Efficiency in Livestock Animals

  摘要：

  本发明揭示了一种通过向动物投与纯或基本纯的RR-异构体的拉克托巴胺的治疗有效量来促进或改善动物的饲料效率和肌肉脂肪比的方法。还揭示了能够增加动物瘦肉沉积或减少体脂肪，或促进或改善动物生长或改善动物饲料效率的动物饲料制剂和组合物以及制药制剂。揭示了包括治疗有效量的纯或基本纯的RR-异构体的拉克托巴胺的动物饲料制剂、组合物和制药制剂。

  公开号：

  US20070282010A1

文献信息

• Somatostatin antagonists and agonists
  申请人：——

  公开号：US20020091090A1

  公开（公告）日：2002-07-11

  Compounds according to the formula A-B-Z-W, wherein A is selected from (C 6 -C 10 )aryl-, or (C 1 -C 9 )heteroaryl-, which groups may be optionally substituted; B is selected from (a) O, NH, NR 10 , —(CH 2 ) k —O—, —(CH 2 ) k —N—, and —(CH 2 ) k —NR 10 —, where R 10 is (C 1 -C 6 )alkyl and where k is 1 to 6 in each case, or 1 where said group (i) through (iv) is optionally substituted by 1 to 4, preferably 1 to 2, groups selected from (C 1 -C 6 )alkyl, halo, and (C 1 -C 6 )alkyl optionally substituted by 1 to 3 halo atoms wherein one of carbon atoms C 1 , C 2 , C 3 and C 4 of said piperidine or piperazine group is optionally replaced by a carbonyl group; Z and W are as herein described; and pharmaceutically acceptable salts, solvates or hydrates thereof; pharmaceutical compositions thereof; and methods useful to facilitate secretion of growth hormone(GH) in mammels.

  根据公式A-B-Z-W，其中 A选自(C6-C10)芳基或(C1-C9)杂环芳基，这些基团可以选择性地被取代； B选自 (a) O、NH、NR10、—(CH2)k—O—、—( )k—N—和—( )k—NR10—，其中R10为(C1-C6)烷基，k在每种情况下为1至6，或 1所述的该组(i)至(iv)可以选择性地被1至4个，优选1至2个，选自(C1-C6)烷基、卤素和(C1-C6)烷基，该烷基可以选择性地被1至3个卤原子取代，其中所述哌啶或哌嗪基团的碳原子C1、C2、C3和C4中的一个可以选择性地被羰基取代； Z和W如本文所述；以及其药学上可接受的盐、溶剂化合物或水合物；其制药组合物；以及用于促进哺乳动物分泌生长激素(GH)的方法。
• Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
  申请人：——

  公开号：US20020091125A1

  公开（公告）日：2002-07-11

  Compounds according to the formula A-Z-W as herein described, wherein A is selected from the groups consisting of: A′—(CH 2 ) n —, A′—(CH 2 ) n SO 2 —, and A′—(CH 2 ) n CO—, where n is 0 to 4; and A′ is selected from (a) (C 6 -C 10 )aryl-, or (b) (C 1 -C 9 )heteroaryl-; which groups may be optionally substituted; and pharmaceutically acceptable salts, solvates or hydrates thereof; pharmaceutical compositions thereof; and methods useful to facilitate secretion of growth hormone(GH) in mammals.

  根据本文描述的公式A-Z-W，其中A是从以下组中选择的：A′—(CH2)n—，A′—( )nSO2—和A′—( )nCO—，其中n为0到4；A′是从(a) (C6-C10)芳基-，或(b) (C1-C9)杂环芳基-中选择的；这些基团可以选择性地被取代；以及其药学上可接受的盐、溶剂化合物或水合物；以及其中的药物组合物；以及用于促进哺乳动物中生长激素（GH）分泌的方法。
• [EN] PROCESS FOR THE PREPARATION OF RACTOPAMINE HYDROCHLORIDE VIA NOVEL INTERMEDIATES<br/>[FR] PROCÉDÉ DE PRÉPARATION DU CHLORHYDRATE DE RACTOPAMINE PAR LE BIAIS DE NOUVEAUX INTERMÉDIAIRES
  申请人：INCHEM LABORATORIES PVT LTD

  公开号：WO2020229935A1

  公开（公告）日：2020-11-19

  The present disclosure describes the new methods of preparation of Ractopamine which are superior to state of art by involving comparatively better and mild reaction conditions. The method of preparation involves following steps: In the first embodiment, 4-(4-hydroxyphenyl)-3-butene-2-one is prepared by condensation of 4-hydroxybenzaldehyde with acetone in the presence of sodium hydroxide/hydrochloric acid. In the next step, 4-(4-hydroxyphenyl)-3-butene-2-one undergoes hydrozination with 4-(-2-amino-1- hydroxyl ethyl) phenolhydrochloride in the presence of base using Pd/C/H2 as a catalyst in methanol/ethanol as solvent to yield Ractopamine base. In another embodiment, advancement over the previous scheme is use of Raney Ni/H2 instead of Pd/C as a catalyst. In yet another embodiment, 2-amino-1-(4-hydroxyphenyl) ethanone hydrochloride reacts with 4-(4-hydroxyphenyl)-butane -2-one in the presence of base and raney nickel/H2 as a catalyst. Compared to the prior art reports where Pd/C was used as a catalyst, Raney Ni is used in the present embodiment which is comparatively economical and better catalyst.

  本公开描述了制备雷克托巴胺的新方法，这些方法优于现有技术，因为涉及相对更好和温和的反应条件。制备方法涉及以下步骤：在第一实施例中，通过在氢氧化钠/盐酸存在下，将对羟基苯甲醛与丙酮缩合制备4-(4-羟基苯基)-3-丁烯-2-酮。在接下来的步骤中，4-(4-羟基苯基)-3-丁烯-2-酮在碱存在下与4-(-2-氨基-1-羟基乙基)苯酚盐酸盐进行氢化反应，使用Pd/C/H2作为催化剂，甲醇/乙醇作为溶剂，得到雷克托巴胺碱。在另一实施例中，相对于先前方案的进展是使用Raney Ni/H2而不是Pd/C作为催化剂。在另一实施例中，2-氨基-1-(4-羟基苯基)乙酮盐酸盐在碱和Raney镍/H2作为催化剂的存在下与4-(4-羟基苯基)-丁烷-2-酮发生反应。与先前报道中使用Pd/C作为催化剂的情况相比，本实施例中使用相对经济且更好的Raney Ni作为催化剂。
• Compositions and methods for inducing adipose tissue cell death
  申请人：——

  公开号：US20040235922A1

  公开（公告）日：2004-11-25

  Pharmaceutical compositions, methods for increasing the rate of apoptosis in adipose tissue cells, and methods of reducing adipose tissue mass in a host, are described. One exemplary pharmaceutical composition, among others, includes at least one catecholamine in combination with a pharmaceutically acceptable carrier. The catecholamine is present in a dosage level effective to increase the rate of apoptosis in adipose tissue cells in a host.

  药物组合物，增加脂肪组织细胞凋亡速率的方法，以及减少宿主体内脂肪组织质量的方法被描述。其中一种示例药物组合物包括至少一种儿茶酚胺与一种药用可接受载体的组合。儿茶酚胺以有效剂量存在，用于增加宿主体内脂肪组织细胞的凋亡速率。
• SARMS AND METHOD OF USE THEREOF
  申请人：Dalton James T.

  公开号：US20100249228A1

  公开（公告）日：2010-09-30

  This invention is directed to a feed composition and method of affecting the carcass composition by increasing the lean mass, reducing the fat mass, and/or reducing the percent fat mass comprising SARM compounds.

  本发明涉及一种饲料组合物和方法，通过增加瘦肉含量、减少脂肪含量和/或减少脂肪百分比含量，其中包括SARM化合物，以影响肉体组成。