1-Butyl hydrogen N-[(phenylmethoxy)carbonyl]-L-glutamate | 88815-55-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Butyl hydrogen N-[(phenylmethoxy)carbonyl]-L-glutamate
• 英文别名: (4S)-5-butoxy-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
• CAS: 88815-55-8
• 化学式: C₁₇H₂₃NO₆
• 分子量: 337.4
• InChiKey: OKVGFKDXOTXSFB-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] METHODS FOR TREATING POST TRAUMATIC STRESS DISORDER<br/>[FR] PROCÉDÉS PERMETTANT DE TRAITER LE TROUBLE DE STRESS POST-TRAUMATIQUE
  申请人：AZEVAN PHARMACEUTICALS INC

  公开号：WO2012003436A1

  公开（公告）日：2012-01-05

  Compounds and compositions are described herein for treating post tramatic stress disorder.

  本文描述了用于治疗创伤后应激障碍的化合物和组合物。
• Glutathione based delivery system
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：EP1891962A1

  公开（公告）日：2008-02-27

  A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.

  一种给药系统。该给药系统包括载体或活性化合物以及接枝在其上的谷胱甘肽或谷胱甘肽衍生物。本发明还提供了一种化合物，其分子包括维生素 E 衍生物或磷脂衍生物、与之结合的聚乙二醇（PEG）或聚乙二醇衍生物，以及与聚乙二醇或聚乙二醇衍生物结合的谷胱甘肽（GSH）或谷胱甘肽衍生物。
• EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT
  申请人：BTG International Limited

  公开号：EP2655398B1

  公开（公告）日：2016-08-24
• US9458188B2
  申请人：——

  公开号：US9458188B2

  公开（公告）日：2016-10-04
• [EN] EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT<br/>[FR] COUPLAGES PEPTIDIQUES EFFICACES ET LEUR UTILISATION DANS LA SYNTHÈSE ET L'ISOLEMENT D'UN SEL TRISODIQUE DE CYCLOPENTA [G] QUINAZOLINE
  申请人：ONYX PHARMA INC

  公开号：WO2012087888A2

  公开（公告）日：2012-06-28

  A new method for the synthesis of L-Glutamyl-γ-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8- tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido) butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.