3-羟基-1-(4-甲氧基苯基)-2-甲基吡啶-4-酮 | 64648-68-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-羟基-1-(4-甲氧基苯基)-2-甲基吡啶-4-酮
• 英文名称: 3-hydroxy-1-(p-methoxyphenyl)-2-methylpyridine-4-one
• 英文别名: 1-(p-methoxyphenyl)-3-hydroxy-2-methyl-4-pyridinone；3-hydroxy-1-(p-methoxyphenyl)-2-methyl-4-pyridinone；3-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-pyridin-4-one；3-Hydroxy-1-(4-methoxyphenyl)-2-methylpyridin-4(1H)-one；3-hydroxy-1-(4-methoxyphenyl)-2-methylpyridin-4-one
• CAS: 64648-68-6
• 化学式: C₁₃H₁₃NO₃
• 分子量: 231.251
• InChiKey: ACFKVGYFOLUBFX-UHFFFAOYSA-N

物化性质

• 沸点：
  386.7±42.0 °C(Predicted)
• 密度：
  1.272±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  aluminum(III) nitrate nonahydrate 、 3-羟基-1-(4-甲氧基苯基)-2-甲基吡啶-4-酮 以 水 为溶剂， 以68%的产率得到tris(3-hydroxy-1-(p-methoxyphenyl)-2-methyl-4-pyridinonato)aluminium(III) hydrate
  参考文献：
  名称：

  Zhang, Zaihui; Rettig, Steven J.; Orvig, Chris, Inorganic Chemistry, 1991, vol. 30, # 3, p. 509 - 515

  摘要：

  DOI：
• 作为产物：
  描述：

  麦芽醇 、 邻甲氧基苯胺 在 对甲苯磺酸 作用下， 以 水 为溶剂， 反应 48.0h， 以65%的产率得到3-羟基-1-(4-甲氧基苯基)-2-甲基吡啶-4-酮
  参考文献：
  名称：

  Synthesis of 3-Hydroxy-1-(p-methoxyphenyl)-2-methylpyridine-4-one and Spectrophotometric Extraction Studies on its Complexation of Vanadium(V)

  摘要：

  In this paper a single step synthesis of 3-hydroxy-1-(p-methoxyphenyl)-2-methylpyridine-4-one (HM) using starting maltol and p-anisidine in the presence of acid catalyst (p-toluenesulfonic acid or HCl) is described. The reaction is carried out by heating the aqueous solution of the reactants and a catalyst in a sealed thick-walled glass tube at 150 degrees C at different reaction times in order to retrieve an optimal yield. The complexation reactions of vanadium(V) with HM as well as the extraction of V(V) from aqueous to organic phase were studied spectrophotometrically. The optimum conditions for extraction of vanadium(V) from aqueous phase, containing chloride or thiocyanate ions, to chloroform solution of HM and complex formation have been evaluated. Based on the results obtained by Job's and equilibrium shift methods the composition of the complexes has been found to be V(V) : Cl(SCN) : HM = 1 : 1 : 2.

  DOI：

  10.5562/cca2366

文献信息

• Synthesis, Crystal and Molecular Structure of Novel Adamantyl Derivatives of N-Aryl Substituted 3-Hydroxy-2-methylpyridine-4-ones
  作者：Vesna Petrović Peroković、Biserka Prugovečki、Željka Car

  DOI：10.5562/cca2339

  日期：——

  Two novel potentially bioactive compounds, esters 2-methyl-1-phenylpyridine-4-one-3-yl adamantan-1-ylethanoate (1) and 1-(p-methoxyphenyl)-2-methylpyridine-4-one-3-yl adamantan-1-ylethanoate (2), were synthesized by esterification of adamantan-l-ylacetic acid with appropriate N-aryl substituted 3-hydroxypyridine-4-one derivatives. Both compounds are fully characterized using standard spectroscopic methods. Crystal and molecular structures of 1 and 2 were determined by the single crystal X-ray diffraction method. The crystal packing of both 1 and 2 shows separation of the hydrophobic and hydrophilic regions. The crystal structure of 1 is characterized by the two-dimensional hydrogen bonding layers parallel to (001). The crystal packing of 2 is characterized by hydrogen-bonded chains extended in the direction [010].
• Zhang, Zaihui; Rettig, Steven J.; Orvig, Chris, Canadian Journal of Chemistry, 1992, vol. 70, # 3, p. 763 - 770
  作者：Zhang, Zaihui、Rettig, Steven J.、Orvig, Chris

  DOI：——

  日期：——
• Synthesis of 3-Hydroxy-1-(p-methoxyphenyl)-2-methylpyridine-4-one and Spectrophotometric Extraction Studies on its Complexation of Vanadium(V)
  作者：Vesna Petrović Peroković、Astrid Gojmerac Ivšić、Željka Car、Srđanka Tomić

  DOI：10.5562/cca2366

  日期：——

  In this paper a single step synthesis of 3-hydroxy-1-(p-methoxyphenyl)-2-methylpyridine-4-one (HM) using starting maltol and p-anisidine in the presence of acid catalyst (p-toluenesulfonic acid or HCl) is described. The reaction is carried out by heating the aqueous solution of the reactants and a catalyst in a sealed thick-walled glass tube at 150 degrees C at different reaction times in order to retrieve an optimal yield. The complexation reactions of vanadium(V) with HM as well as the extraction of V(V) from aqueous to organic phase were studied spectrophotometrically. The optimum conditions for extraction of vanadium(V) from aqueous phase, containing chloride or thiocyanate ions, to chloroform solution of HM and complex formation have been evaluated. Based on the results obtained by Job's and equilibrium shift methods the composition of the complexes has been found to be V(V) : Cl(SCN) : HM = 1 : 1 : 2.
• Zhang, Zaihui; Rettig, Steven J.; Orvig, Chris, Inorganic Chemistry, 1991, vol. 30, # 3, p. 509 - 515
  作者：Zhang, Zaihui、Rettig, Steven J.、Orvig, Chris

  DOI：——

  日期：——