2[bis-(4-Fluorobenzyl)amino]-5-amino-indane | 371254-92-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2[bis-(4-Fluorobenzyl)amino]-5-amino-indane
• 英文别名: 2-N,2-N-bis[(4-fluorophenyl)methyl]-2,3-dihydro-1H-indene-2,5-diamine
• CAS: 371254-92-1
• 化学式: C₂₃H₂₂F₂N₂
• 分子量: 364.438
• InChiKey: ZAXPMNZGEYZUGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives
  申请人：——

  公开号：US20030220382A1

  公开（公告）日：2003-11-27

  The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R 1 and R 2 include alkyl and phenylalkyl; R 3 is hydrogen or alkyl; and R 4 and R 5 include alkyl, alkoxy, carboxyl, alkoxycarbonyl, and nitro. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using compounds of Formula (I). 1

  本发明提供了公式（I）的化合物以及使用公式（I）的化合物治疗阿尔茨海默病的方法，其中：R1和R2包括烷基和苯基烷基；R3是氢或烷基；R4和R5包括烷基，烷氧基，羧基，烷氧羰基和硝基。还提供了使用公式（I）的化合物抑制淀粉样蛋白聚集的方法以及使用公式（I）的化合物成像淀粉样沉积物的方法。
• METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING AMINOIDANE DERIVATIVES
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1284958A1

  公开（公告）日：2003-02-26
• US6949575B2
  申请人：——

  公开号：US6949575B2

  公开（公告）日：2005-09-27
• [EN] METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING AMINOINDANE DERIVATIVES<br/>[FR] PROCEDE D'INHIBITION DE L'AGREGATION DE PROTEINES AMYLOIDES ET D'IMAGERIE DE DEPOTS AMYLOIDES FAISANT APPEL A DES DERIVES AMINO-INDANES
  申请人：WARNER LAMBERT CO

  公开号：WO2001083425A1

  公开（公告）日：2001-11-08

  The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R?1 and R2¿ include alkyl and phenylalkyl; R3 is hydrogen or alkyl; and R¿4? and R5 include alkyl, alkoxy, carboxyl, alkoxycarbonyl, and nitro. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using compounds of Formula (I).