tianeptine hydrochloride | 1159812-13-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: tianeptine hydrochloride
• 英文别名: 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide hydrochloride；7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid;hydrochloride
• CAS: 1159812-13-1
• 化学式: C₂₁H₂₅ClN₂O₄S*ClH
• 分子量: 473.42
• InChiKey: VALUNVMGXVWSGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.61
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  95.1
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (+)-噻奈普汀单钠盐 在 盐酸 作用下， 以 水 为溶剂， 生成 tianeptine hydrochloride
  参考文献：
  名称：

  TIANEPTINE SULFATE SALT FORMS AND METHODS OF MAKING AND USING THE SAME

  摘要：

  本文披露了一种具有改进性能的替格瑞派钠的新型硫酸盐。本文还描述了包含替格瑞派钠硫酸盐的新型药物组合物，制备方法以及相关治疗方法。

  公开号：

  US20100112051A1

文献信息

• COMBINATION OF M-OPIOID RECEPTOR (MOR) MODULATORS FOR PREVENTING AND TREATING PAIN, SUICIDALITY AND MENTAL DISORDERS
  申请人：Hadasit Medical Research Services and Development Ltd.

  公开号：EP3873447A1

  公开（公告）日：2021-09-08
• MAINTENANCE THERAPY USING TIANEPTINE
  申请人：GENOMIND, Inc.

  公开号：US20180042936A1

  公开（公告）日：2018-02-15

  The present application provides a method for treating treatment-resistant depression in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of tianeptine, subsequent to a ketamine treatment; also provided is a method of treating suicidal ideation (SI), post-traumatic stress disorder (PTSD), mild cognitive impairment (MCI) or pre-dementia co-morbid with symptoms of depression; and further provided is maintenance therapy for depression remission.
• US8198268B2
  申请人：——

  公开号：US8198268B2

  公开（公告）日：2012-06-12
• [EN] TIANEPTINE SULFATE SALT FORMS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] FORMES SALINES DE SULFATE DE TIANEPTINE ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：TRANSFORM PHARMACEUTICALS INC

  公开号：WO2010051239A1

  公开（公告）日：2010-05-06

  Disclosed herein is a novel sulfate salt of tianeptine with improved properties. Also described herein are novel pharmaceutical compositions comprising tianeptine sulfate salt, methods of making, and related methods of treatment.
• TIANEPTINE SULFATE SALT FORMS AND METHODS OF MAKING AND USING THE SAME
  申请人：Guzman Hector

  公开号：US20100112051A1

  公开（公告）日：2010-05-06

  Disclosed herein is a novel sulfate salt of tianeptine with improved properties. Also described herein are novel pharmaceutical compositions comprising tianeptine sulfate salt, methods of making, and related methods of treatment.

  本文披露了一种具有改进性能的替格瑞派钠的新型硫酸盐。本文还描述了包含替格瑞派钠硫酸盐的新型药物组合物，制备方法以及相关治疗方法。