azidoGly-Pro-Lys-Lys-Lys-Arg-Lys-Val-NH2 | 1430654-09-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: azidoGly-Pro-Lys-Lys-Lys-Arg-Lys-Val-NH2
• CAS: 1430654-09-3
• 化学式: C₄₂H₈₀N₁₈O₈
• 分子量: 965.213
• InChiKey: BCQZMWOJAAXVJE-SLJYAKFTSA-N

反应信息

• 作为反应物：
  描述：

  、 azidoGly-Pro-Lys-Lys-Lys-Arg-Lys-Val-NH2 在 tetrakis(actonitrile)copper(I) hexafluorophosphate 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以15.5 mg的产率得到8-{4-(1-(2-((S)-2-(((3S,6S,9S,12S,15S,18S)-22-amino-6,12,15-tris(4-amino-butyl)-3-carbamoyl-9-(3-guanidinopropyl)-2-methyl-5,8,11,14,17-penta-oxo-4,7,10,13,16-pentaazadocosan-18-yl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)phenyl}4,4-di-fluoro-2,6-diiodo-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene
  参考文献：
  名称：

  Synthesis and in vitro evaluation of a PDT active BODIPY–NLS conjugate

  摘要：

  Two new photosensitizers based on the BODIPY scaffold have been synthesized, of which one bears an NLS peptide, which is linked to the BODIPY's core using the copper catalysed azide-alkyne click reaction. The phototoxicities of these BODIPY based photosensitizers have been determined, as well as their dark toxicities. Although the conjugation of a single NLS peptide to the BODIPY did not lead to any observable nuclear localization, the photosensitizer did exhibit a superior photoxicity. Cellular co-localization experiments revealed a localization of both dyes in the lysosomes, as well as a partial localization within the ER (for the peptide-bearing BODIPY). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.03.128