5-chloro-1-(4-methoxy-benzyl)-2-(4-methoxy-phenyl)-1H-benzimidazole | 102548-71-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-chloro-1-(4-methoxy-benzyl)-2-(4-methoxy-phenyl)-1H-benzimidazole
• 英文别名: 5-Chlor-1-(4-methoxy-benzyl)-2-(4-methoxy-phenyl)-1H-benzimidazol
• CAS: 102548-71-0
• 化学式: C₂₂H₁₉ClN₂O₂
• 分子量: 378.858
• InChiKey: UDLOIXFAYNXOJY-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 对甲苯磺酸 作用下， 以 neat (no solvent) 为溶剂， 以82%的产率得到5-chloro-1-(4-methoxy-benzyl)-2-(4-methoxy-phenyl)-1H-benzimidazole
  参考文献：
  名称：

  Facile Synthesis of 1,2-Disubstituted Benzimidazoles Usingp-Toluenesulfonic Acid through Grinding Method

  摘要：

  An efficient synthetic method for the highly selective synthesis of pharmacologically active 1,2-disubstituted benzimidazole derivatives fromo-phenylenediamine and various aromatic aldehydes catalyzed byp-toluenesulfonic acid through grinding under solvent-free condition is described. The reaction requires the catalyst only during the conversion of intermediateN,N '-dibenzylidene-o-phenylenediamine into the desired product. The products were obtained within a short time with good yields by using only a mortar and pestle, which makes the proposed method convenient and cost-effective.

  DOI：

  10.1134/s1070428020090201

文献信息

• Rao; Ratnam, Proceedings - Indian Academy of Sciences, Section A, 1958, # 48, p. 256,258, 260
  作者：Rao、Ratnam

  DOI：——

  日期：——