(E)-N-Benzyl-2-methoxycinnamamidine hydrochloride | 381690-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-N-Benzyl-2-methoxycinnamamidine hydrochloride
• 英文别名: (E)-N'-benzyl-3-(2-methoxyphenyl)prop-2-enimidamide;hydrochloride
• CAS: 381690-79-5
• 化学式: C₁₇H₁₈N₂O*ClH
• 分子量: 302.804
• InChiKey: SCLRIHJLMJNWLZ-CALJPSDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  47.6
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Amidine derivatives as selective antagonists of ndma receptors
  申请人：——

  公开号：US20030119871A1

  公开（公告）日：2003-06-26

  A class of styryl amidine derivatives which are antagonists of the hum NMDA receptor, being selective for those containing the NR2B subunit, are active in the treatment and/or prevention of neurological and neurodegenerative disorders, in particular neuropathic pain and headache, specifically migraine, whils displaying fewer ataxic and related side-effects associated with other classes of NMDA receptor antagonists.

  一类styryl amidine衍生物，它们是hum NMDA受体的拮抗剂，对含有NR2B亚基的受体具有选择性，在治疗和/或预防神经系统和神经退行性疾病方面具有活性，特别是神经病性疼痛和头痛，特别是偏头痛，同时显示出更少的共济失调和其他NMDA受体拮抗剂相关的副作用。
• AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1296940A1

  公开（公告）日：2003-04-02
• [EN] AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS<br/>[FR] DERIVES D'AMIDINE EN TANT QU'ANTAGONISTES SELECTIFS DE RECEPTEURS NMDA
  申请人：MERCK SHARP & DOHME

  公开号：WO2001098262A1

  公开（公告）日：2001-12-27

  A class of styryl amidine derivatives which are antagonists of the hum NMDA receptor, being selective for those containing the NR2B subunit, are active in the treatment and/or prevention of neurological and neurodegenerative disorders, in particular neuropathic pain and headache, specifically migraine, whils displaying fewer ataxic and related side-effects associated with other classes of NMDA receptor antagonists.