(2S,4R)-1-ethyl-4-hydroxypyrrolidine-2-carboxylic acid | 1024616-56-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4R)-1-ethyl-4-hydroxypyrrolidine-2-carboxylic acid
• CAS: 1024616-56-5
• 化学式: C₇H₁₃NO₃
• 分子量: 159.185
• InChiKey: CVJUXHLVXPZWPB-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-fluorophenyl)-5-(piperidin-4-yl)-3-(pyridin-4-yl)-pyrrole 、 (2S,4R)-1-ethyl-4-hydroxypyrrolidine-2-carboxylic acid 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 1-羟基苯并三唑 、 N,N-二异丙基乙胺 作用下， 生成
  参考文献：
  名称：

  N-Alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents

  摘要：

  Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anti-coccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.104

文献信息

• [EN] OXAZOLE PYRIDINE DERIVATIVES USEFUL AS S1P1 RECEPTOR AGONISTS<br/>[FR] DÉRIVÉS D'OXAZOLE PYRIDINE UTILES EN TANT QU'AGONISTES DU RÉCEPTEUR S1P1
  申请人：MERCK SERONO SA

  公开号：WO2010100142A1

  公开（公告）日：2010-09-10

  The present invention provides oxadiazole pyridine derivatives of Formula (I), their use as medicaments and their use for treating multiple sclerosis and other diseases.

  本发明提供了式（I）的噁二唑吡啶衍生物，以及它们作为药物的用途，用于治疗多发性硬化症和其他疾病。
• COMPOUNDS
  申请人：Deng Guanghui

  公开号：US20110269738A1

  公开（公告）日：2011-11-03

  The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

  本发明涉及具有药理活性的新化合物，其制备方法，含有它们的药物组合物以及它们在治疗各种疾病中的用途。
• [EN] SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS<br/>[FR] COMPOSÉS DE TYPE PYRIMIDINE SUBSTITUÉE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DES KINASES SYK
  申请人：GENOSCO

  公开号：WO2013109882A1

  公开（公告）日：2013-07-25

  Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

  公式（I）的化合物和抑制激酶的方法被揭示。还揭示了通过向受试者投予公式（I）的化合物的治疗有效量来治疗激酶介导的疾病或病况的方法。
• SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS
  申请人：OSCOTEC, INC.

  公开号：US20130274242A1

  公开（公告）日：2013-10-17

  Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

  本文披露了化学式(I)的化合物及其抑制酶，包括脾酪氨酸激酶的方法。同时还披露了通过向受试者施用化学式(I)化合物的治疗有效剂量来治疗酶介导的疾病或状况的方法。
• Novel Ligands and Libraries of Ligands
  申请人：Braisted Andrew C.

  公开号：US20120077711A1

  公开（公告）日：2012-03-29

  The present invention provides compounds and libraries of compounds having formula (I): wherein L, n, S and A are defined generally and subsets herein. These compounds and libraries of compounds are useful generally in the drug discovery process.