3,5-Diiodo-O-(3-iodophenyl)-L-tyrosine | 51725-31-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,5-Diiodo-O-(3-iodophenyl)-L-tyrosine
• 英文别名: (2S)-2-amino-3-[3,5-diiodo-4-(3-iodophenoxy)phenyl]propanoic acid
• CAS: 51725-31-6
• 化学式: C₁₅H₁₂I₃NO₃
• 分子量: 634.97
• InChiKey: RYNFIHJMHIOLDH-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• A PHARMACEUTICAL COMPOSITION COMPRISING A SULFATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE
  申请人：Bracco Imaging SPA

  公开号：EP3260443A1

  公开（公告）日：2017-12-27

  The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

  本发明涉及一种以相应的酚类化合物为起点，在氯磺酸和二甲基乙酰胺作为溶剂的存在下，制备衍生物 3,5-二碘-O-[3-碘-4-(磺氧基)苯基]-L-酪氨酸（T3S）的单钠盐的工艺。这样得到的 T3S 化合物可以很方便地以纯固体形式分离出来，收率很高。 本发明进一步涉及 T3S 的制备过程，其中起始试剂为 T2，并进一步包括将这种化合物制成片剂。 此外，本发明还公开了基于 T3S 衍生物的非放射性免疫测定。
• A NON-RADIOACTIVE IMMUNO-ASSAY FOR 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE DETECTION AND QUANTITATION
  申请人：Bracco Imaging SPA

  公开号：EP3736264A1

  公开（公告）日：2020-11-11

  The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

  本发明涉及一种以相应的酚类化合物为起点，在氯磺酸和二甲基乙酰胺作为溶剂的存在下，制备衍生物 3,5-二碘-O-[3-碘-4-(磺氧基)苯基]-L-酪氨酸（T3S）的单钠盐的工艺。这样得到的 T3S 化合物可以很方便地以纯固体形式分离出来，收率很高。 本发明进一步涉及 T3S 的制备过程，其中起始试剂为 T2，并进一步包括将这种化合物制成片剂。 此外，本发明还公开了基于 T3S 衍生物的非放射性免疫测定。
• Process for the preparation of a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine
  申请人：BRACCO IMAGING S.p.A.

  公开号：US10457635B2

  公开（公告）日：2019-10-29

  The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

  本发明涉及一种以相应的酚类化合物为起点，在氯磺酸和二甲基乙酰胺作为溶剂的存在下，制备衍生物 3,5-二碘-O-[3-碘-4-(磺氧基)苯基]-L-酪氨酸（T3S）的单钠盐的工艺。这样得到的 T3S 化合物可以很方便地以纯固体形式分离出来，收率很高。 本发明进一步涉及 T3S 的制备过程，其中起始试剂为 T2，并进一步包括将这种化合物制成片剂。 此外，本发明还公开了基于 T3S 衍生物的非放射性免疫测定。
• PROCESS FOR THE PREPARATION OF A SULFATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE
  申请人：Bracco Imaging S.p.A.

  公开号：EP2694471B1

  公开（公告）日：2017-08-02
• Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine
  申请人：Anelli Pier Lucio

  公开号：US20140024717A1

  公开（公告）日：2014-01-23

  The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chloro-sulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.