(1S,9S)-9-[(S)-1-ethoxycarbonyl-3-phenylpropylamino)-10-oxooctahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid 1-chloroethyl ester | 1416728-94-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1S,9S)-9-[(S)-1-ethoxycarbonyl-3-phenylpropylamino)-10-oxooctahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid 1-chloroethyl ester
• 英文别名: 1-chloroethyl (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylate
• CAS: 1416728-94-3
• 化学式: C₂₄H₃₄ClN₃O₅
• 分子量: 480.004
• InChiKey: QWDBAJFHQHONDX-QNWZQLASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  88.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Prodrugs of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their use in transdermal therapeutic systems
  申请人：Hexal AG

  公开号：EP2537534A1

  公开（公告）日：2012-12-26

  The present invention relates to diester prodrugs of cilazaprilate which undergo enzymatic cleavage to release the active metabolite cilazaprilate that is used for the treatment of hypertension and congestive heart failure. Furthermore the diester prodrugs of cilazaprilate possess all the properties necessary to be topically administered, preferably via transdermal therapeutic systems.

  本发明涉及西拉普利酸二酯原药，该原药经过酶裂解后释放出活性代谢物西拉普利酸，用于治疗高血压和充血性心力衰竭。此外，西拉普利酸二酯原药具有局部给药所需的所有特性，最好是通过透皮治疗系统给药。
• Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.
  申请人：Hexal AG

  公开号：EP2537534B1

  公开（公告）日：2014-12-17
• PRODRUGS OF (1S,9S)-9-[[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO]OCTAHYDRO-10-OXO-6H-PYRIDAZINO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLIC ACID AND THEIR USE IN TRANSDERMAL THERAPEUTIC SYSTEMS
  申请人：Bernhardt Günther

  公开号：US20140147477A1

  公开（公告）日：2014-05-29

  The present invention relates to diester prodrugs of cilazaprilate which undergo enzymatic cleavage to release the active metabolite cilazaprilate that is used for the treatment of hypertension and congestive heart failure. Furthermore the diester prodrugs of cilazaprilate possess all the properties necessary to be topically administered, preferably via transdermal therapeutic systems.
• US8785431B2
  申请人：——

  公开号：US8785431B2

  公开（公告）日：2014-07-22