(3S,6S,10aR)-Ethyl 6-((tert-butoxycarbonyl)amino)-5-oxo-1,2,3,5,6,7,10,10a-octahydropyrrolo[1,2-a]azocine-3-carboxylate | 549521-78-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S,6S,10aR)-Ethyl 6-((tert-butoxycarbonyl)amino)-5-oxo-1,2,3,5,6,7,10,10a-octahydropyrrolo[1,2-a]azocine-3-carboxylate
• 英文别名: ethyl (3S,6S,8Z,10aR)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxo-2,3,6,7,10,10a-hexahydro-1H-pyrrolo[1,2-a]azocine-3-carboxylate
• CAS: 549521-78-0
• 化学式: C₁₈H₂₈N₂O₅
• 分子量: 352.4
• InChiKey: JSPQCKZOXNWHSV-OOBDJQDNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Neuroprotective macrocyclic compounds and methods for their use
  申请人：Harris William Richard Paul

  公开号：US20060217295A1

  公开（公告）日：2006-09-28

  Embodiments of this invention provide novel peptidomimetics that contain a macrocycle. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterised by neuronal degeneration and/or death. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.

  本发明的实施例提供了含有大环的新型肽类似物。这些化合物具有神经保护作用，并可用作治疗由神经元退化和/或死亡所表征的疾病、损伤和其他情况的治疗剂。这些化合物还可用于制造用于治疗此类疾病的药物。
• Conformationally Constrained Smac Mimetics and the Uses Thereof
  申请人：Wang Shaomeng

  公开号：US20080269140A1

  公开（公告）日：2008-10-30

  The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

  本发明涉及结构受限的Smac类拟态物，其作为抑制凋亡抑制蛋白的抑制剂。本发明还涉及使用这些拟态物诱导细胞凋亡和增强细胞对凋亡诱导剂的敏感性。
• STAT3 LIGANDS AND THERAPEUTIC USES THEREOF
  申请人：Wang Shaomeng

  公开号：US20110319362A1

  公开（公告）日：2011-12-29

  Inhibitors of STAT3 are disclosed. Methods of using the STAT3 inhibitors in the treatment of diseases and conditions wherein inhibition of STAT3 provides a benefit, like cancers, also are disclosed.
• US7485630B2
  申请人：——

  公开号：US7485630B2

  公开（公告）日：2009-02-03
• US7932382B2
  申请人：——

  公开号：US7932382B2

  公开（公告）日：2011-04-26