| 1149370-62-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1149370-62-6
• 化学式: C₂₉H₃₄N₂O₆S
• 分子量: 538.665
• InChiKey: AFEDKWCWVZOJTE-ABYGYWHVSA-N

物化性质

• 沸点：
  703.9±70.0 °C(predicted)
• 密度：
  1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以 氯仿 为溶剂， 反应 12.0h， 生成 (1R,2S)-1-{[4-(3-hydroxyprop-1-yn-1-yl)benzene][2-(2-oxopyrrolidin-1-yl)ethyl]sulfonamido}-2-phenylcyclopropane-1-carboxylic acid
  参考文献：
  名称：

  Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors

  摘要：

  A series of N-substituted sulfonylamino-alkanecarboxylate ADAMTS-5 (Aggrecanase-2) inhibitors has been synthesized and the in vitro enzyme SAR is discussed. This report is the first example of carboxylate-based ADAMTS-5 inhibitors which show strong potency of IC50 < 0.1 mu M with excellent selectivity over MMP-1 and TACE. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.024