2-Pentafluorophenyl-pentanedioic acid | 68596-28-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Pentafluorophenyl-pentanedioic acid
• 英文别名: 2-(2,3,4,5,6-Pentafluorophenyl)pentanedioic acid
• CAS: 68596-28-1
• 化学式: C₁₁H₇F₅O₄
• 分子量: 298.166
• InChiKey: DTBVECRRXGADIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• US20140343123A1
  申请人：——

  公开号：US20140343123A1

  公开（公告）日：2014-11-20
• COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：US20150126719A1

  公开（公告）日：2015-05-07

  Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoCIII). In certain embodiments, the ApoCIII targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting ApoCIII for use in decreasing ApoCIII to treat, prevent, or ameliorate diseases, disorders or conditions related to ApoCIII. Certain diseases, disorders or conditions related to ApoCIII include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
• US9163239B2
  申请人：——

  公开号：US9163239B2

  公开（公告）日：2015-10-20