N-Methyl-L-isoleucinamide | 1248962-23-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Methyl-L-isoleucinamide
• 英文别名: (2S,3S)-3-methyl-2-(methylamino)pentanamide
• CAS: 1248962-23-3
• 化学式: C₇H₁₆N₂O
• 分子量: 144.21
• InChiKey: CAAAQGIZHMERNZ-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION<br/>[FR] ANALOGUES DE LA TUBULYSINE ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：PFIZER

  公开号：WO2017134547A1

  公开（公告）日：2017-08-10

  The present invention is directed to novel cytotoxic tubulysin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.

  本发明涉及新的细胞毒性的管素类似物和衍生物，以及它们的抗体药物偶联物，以及使用它们治疗包括癌症在内的医疗状况的方法。
• METHOD FOR PREPARING OPTICALLY ACTIVE N-METHYLAMINO ACIDS AND OPTICALLY ACTIVE N-METHYLAMINO ACID AMIDES
  申请人：Arie Sachiko

  公开号：US20130041178A1

  公开（公告）日：2013-02-14

  The present invention relates to a method for preparing optically active N-methylamino acids and/or optically active N-methylamino acid amides by subjecting the cells or treatment products of a microorganism belonging to the Mycoplana genus to the hydrolysis with N-methylamino acid amide to give an optically active N-methylamino acid and an optically active N-methylamino acid amide. According to the present invention, optically active N-methylamino acids and optically active N-methylamino acid amides useful as the raw material of pharmaceuticals can be stereoselectively obtained with good efficiency.

  本发明涉及一种通过将属于Mycoplanagenus微生物的细胞或处理产物暴露于N-甲基氨基酸酰胺的水解作用，从而得到一种光学活性的N-甲基氨基酸和一种光学活性的N-甲基氨基酸酰胺的方法。根据本发明，可以高效地立体选择性地获得用作药物原料的光学活性N-甲基氨基酸和光学活性N-甲基氨基酸酰胺。
• Anti-inflammatory tripeptides
  申请人：Dr. August Wolff Gmbh & Co. KG Arzneimittel

  公开号：US10954269B2

  公开（公告）日：2021-03-23

  The present invention relates to tripeptide compounds according to the general formula (1) and their use as a medicament, in particular as anti-inflammatory agents.

  本发明涉及通式（1）的三肽化合物及其作为药物的用途，特别是作为抗炎剂的用途。
• TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION
  申请人：Pfizer Inc.

  公开号：EP3411371A1

  公开（公告）日：2018-12-12
• SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS
  申请人：MAX-PLANCK-GESELLSCHART ZUR FÖRDERUNG DER WISSENSC HAFTEN E.V.

  公开号：US20160289184A1

  公开（公告）日：2016-10-06

  The present invention relates to compounds of the general formula (I) having a selective FKBP51 ligand scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said selective FKBP51 ligand compounds can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.