| 1215080-21-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1215080-21-9
• 化学式: C₁₃H₂₂O₄
• 分子量: 242.315
• InChiKey: XEGDWLDYLWQZPG-GTFYECCDSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 12.0h， 以0.37 g的产率得到(4S,5R)-4-vinyl-5-[(R)-1-hydroxypropyl]-4,5-dihydro-2(3H)-furanone
  参考文献：
  名称：

  Synthesis of β,γ-disubstituted-γ-lactones through a Johnson–Claisen rearrangement: a short route to xylobovide, nor-canadensolide, canadensolide, sporothriolide and santolinolide

  摘要：

  The Johnson-Claisen rearrangement of allyl alcohols with chiral vicinal diol functionality was employed to access chiral beta,gamma-disubstituted-gamma-lactones in high enantio- and diastereoselectivity. These were efficiently converted into nor-canadensolide, the advanced gamma-(lactone-lactol) intermediate for xylobovide, canadensolide and sporothriolide and the lactone moiety of the santolinolides. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.11.018