(2-Bromo-propyl)-[2-(4-chloro-phenyl)-ethyl]-amine | 847063-14-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Bromo-propyl)-[2-(4-chloro-phenyl)-ethyl]-amine
• 英文别名: 2-bromo-N-[2-(4-chlorophenyl)ethyl]propan-1-amine
• CAS: 847063-14-3
• 化学式: C₁₁H₁₅BrClN
• 分子量: 276.6
• InChiKey: DLUOOSBAMUVXIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Processes for preparing 3-benzazepines
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP2332919A2

  公开（公告）日：2011-06-15

  The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.

  本发明提供了制备 3-苯并氮杂卓及其盐类的工艺和中间体，这些工艺和中间体可用作血清素（5-HT）受体激动剂，用于治疗肥胖等中枢神经系统疾病。
• Processes for the Separation of 3-Benzazepine Racemates
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP2189448B1

  公开（公告）日：2014-01-29
• Processes for Preparing 3-Benzazepines
  申请人：Wolgast Beverly L.

  公开号：US20080045502A1

  公开（公告）日：2008-02-21

  The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
• PROCESSES FOR PREPARING 3-BENZAZEPINES
  申请人：Wolgast Beverly L.

  公开号：US20130165648A1

  公开（公告）日：2013-06-27

  The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
• US8367657B2
  申请人：——

  公开号：US8367657B2

  公开（公告）日：2013-02-05