3,5-Bis(trifluormethyl)-t-β-methylstyrol | 66875-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Bis(trifluormethyl)-t-β-methylstyrol
• 英文别名: 3,5-Bis-(trifluormethyl)-trans-β-methylstyrol；Benzene, 1-(1-propenyl)-3,5-bis(trifluoromethyl)-, (E)-；1-[(E)-prop-1-enyl]-3,5-bis(trifluoromethyl)benzene
• CAS: 66875-49-8
• 化学式: C₁₁H₈F₆
• 分子量: 254.175
• InChiKey: GOFZTIWCMMRMGL-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20150284387A1

  公开（公告）日：2015-10-08

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

  这项发明属于药物化学领域。具体来说，该发明涉及一类具有吡唑吡啶结构的新型小分子，其作为Mcl-1蛋白抑制剂的功能，以及它们作为治疗癌症和其他疾病的药物的用途。
• CARBOXAMIDE COMPOUNDS AND THEIR USE
  申请人：Lin Jian

  公开号：US20100210633A1

  公开（公告）日：2010-08-19

  Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

  本文介绍了化学因子受体拮抗剂，特别是公式(I)化合物，它们作为化学因子CCR2受体的拮抗剂，包括制药组合物及其用途，用于治疗或预防与单核细胞聚集、淋巴细胞聚集或白细胞聚集相关的疾病。
• Method for directed catalytic functionalization of alcohols
  申请人：The University of Georgia Research Foundation, Inc.

  公开号：US10005719B1

  公开（公告）日：2018-06-26

  A method of preparing ortho-alkenyl and ortho-acetyl benzylic alcohols is disclosed.

  本发明公开了一种制备邻烯基和邻乙酰基苯甲醇的方法。
• COMPOSITION FOR TREATING INFECTIOUS DISEASES
  申请人：Sancho Sanz Javier

  公开号：US20100087690A1

  公开（公告）日：2010-04-08

  Compounds of the general formula (I) or salts thereof, for use as a pharmaceutical composition for treating infectious diseases, especially for treating diseases caused by Helicobacter are disclosed. R 1 is an H atom, an X atom or a CX m H 3-m radical wherein each X can be the same or different and is a halogen selected from F, Cl, Br or I, and m is an integer between 1 and 3; R 2 is an NO 2 group, a COOR′ group or an SO 3 R′ group; R′ is a hydrogen (H) atom or a C 1 -C 6 alkyl group; and n is an integer between 1 and 5.
• US7326727B2
  申请人：——

  公开号：US7326727B2

  公开（公告）日：2008-02-05