tert-butyl (4-((2S,5S,8R,11S,14S)-14-benzyl-5,11-diisobutyl-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)carbamate | 1252661-00-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (4-((2S,5S,8R,11S,14S)-14-benzyl-5,11-diisobutyl-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)carbamate
• CAS: 1252661-00-9
• 化学式: C₃₇H₆₀N₆O₇
• 分子量: 700.919
• InChiKey: AJAFINWTXHEEKG-VFFRCKCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.11
• 重原子数：
  50.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  183.83
• 氢给体数：
  6.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  tert-butyl (4-((2S,5S,8R,11S,14S)-14-benzyl-5,11-diisobutyl-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)carbamate 在 苯甲醚 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到cyclo[Leu-Phe-Lys-Leu-D-Val]
  参考文献：
  名称：

  Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives

  摘要：

  Utilizing the structure-activity relationship we have developed during the synthesis of the first two generations and mechanism of action studies that point to the interaction of these molecules with the key oncogenic protein Hsp90, we report here the design of 32 new Sansalvamide A derivatives and their synthesis. Our new structures, designed from previously reported potent compounds, were tested for cytotoxicity on the HCT116 colon cancer cell line, and their binding to the biological target was analyzed using computational studies involving blind docking of derivatives using Autodock. Further, we show new evidence that our molecules bind directly to Hsp90 and modulate Hsp90's binding with client proteins. Finally, we demonstrate that we have integrated good ADME properties into a new derivative. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.07.042
• 作为产物：
  描述：

  NH2-D-Val-Leu-Phe-Lys(Boc)-Leu-OH 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 二氯甲烷 为溶剂， 以44.5%的产率得到tert-butyl (4-((2S,5S,8R,11S,14S)-14-benzyl-5,11-diisobutyl-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)carbamate
  参考文献：
  名称：

  Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives

  摘要：

  Utilizing the structure-activity relationship we have developed during the synthesis of the first two generations and mechanism of action studies that point to the interaction of these molecules with the key oncogenic protein Hsp90, we report here the design of 32 new Sansalvamide A derivatives and their synthesis. Our new structures, designed from previously reported potent compounds, were tested for cytotoxicity on the HCT116 colon cancer cell line, and their binding to the biological target was analyzed using computational studies involving blind docking of derivatives using Autodock. Further, we show new evidence that our molecules bind directly to Hsp90 and modulate Hsp90's binding with client proteins. Finally, we demonstrate that we have integrated good ADME properties into a new derivative. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.07.042