ethyl 5-tert-butyl-4-ethoxymethyl-2-methylfuran-3-carboxylate | 510773-71-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: ethyl 5-tert-butyl-4-ethoxymethyl-2-methylfuran-3-carboxylate
• 英文别名: ethyl 5-tert-butyl-4-(ethoxymethyl)-2-methylfuran-3-carboxylate
• CAS: 510773-71-4
• 化学式: C₁₅H₂₄O₄
• 分子量: 268.353
• InChiKey: HJTLSSWRXDBNFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  48.67
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  ethyl 5-tert-butyl-4-ethoxymethyl-2-methylfuran-3-carboxylate 在 吡啶 、 lithium aluminium tetrahydride 、 氯化亚砜 作用下， 以 乙醚 为溶剂， 反应 4.0h， 生成 5-tert-butyl-3-chloromethyl-4-ethoxymethyl-2-methylfuran
  参考文献：
  名称：

  摘要：

  Reduction of 2- and 4-acetoxymethyl derivatives of 5-tert-butylfuran-3-carboxylic acid leads to the corresponding bis(hydroxymethyl)furans. Bis(chloromethyl)furans prepared from the latter were involved in reaction with sodium diethyl phosphite. In the presence of two equivalents of a phosphorus-containing nucleophile, bis(phosphonomethyl)furans are formed. One equivalent of sodium diethyl phosphite reacts with 3,4-bis(chloromethyl)furan to give a mixture of 3-and 4-phosphorylated products in a 4.5:1 ratio in a low yield. The revealed difference in reactivity between the 3- and 4-chloromethyl groups demonstrates the importance of shielding of the chloromethyl group by the neighboring tert-butyl substituent. Examination of the H-1 NMR spectra of 3,4-bis(hydroxymethyl)-, 3,4-bis(chloromethyl)-, 3,4-bis(diethoxyphosphorylmethyl)5-tert-butylfurans, and also specially prepared 5-tert-butyl-3-(diethoxyphosphorylmethyl)-4-(ethoxymethyl)-2-methylfuran established that the signal of the substituent neighboring to the tert-butyl group is always shifted downfield.

  DOI：

  10.1023/a:1021605324604
• 作为产物：
  描述：

  sodium ethanolate 、 ethyl 2-methyl-4-chloromethyl-5-tert-butylfuran-3-carboxylate 以 甲苯 为溶剂， 反应 15.0h， 以8.7 g的产率得到ethyl 5-tert-butyl-4-ethoxymethyl-2-methylfuran-3-carboxylate
  参考文献：
  名称：

  摘要：

  Reduction of 2- and 4-acetoxymethyl derivatives of 5-tert-butylfuran-3-carboxylic acid leads to the corresponding bis(hydroxymethyl)furans. Bis(chloromethyl)furans prepared from the latter were involved in reaction with sodium diethyl phosphite. In the presence of two equivalents of a phosphorus-containing nucleophile, bis(phosphonomethyl)furans are formed. One equivalent of sodium diethyl phosphite reacts with 3,4-bis(chloromethyl)furan to give a mixture of 3-and 4-phosphorylated products in a 4.5:1 ratio in a low yield. The revealed difference in reactivity between the 3- and 4-chloromethyl groups demonstrates the importance of shielding of the chloromethyl group by the neighboring tert-butyl substituent. Examination of the H-1 NMR spectra of 3,4-bis(hydroxymethyl)-, 3,4-bis(chloromethyl)-, 3,4-bis(diethoxyphosphorylmethyl)5-tert-butylfurans, and also specially prepared 5-tert-butyl-3-(diethoxyphosphorylmethyl)-4-(ethoxymethyl)-2-methylfuran established that the signal of the substituent neighboring to the tert-butyl group is always shifted downfield.

  DOI：

  10.1023/a:1021605324604