Cu(2+)*[Ac-Thr-Glu-Ala-His-His-Lys-NH2 hexapeptide] complex | 503417-04-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cu(2+)*[Ac-Thr-Glu-Ala-His-His-Lys-NH2 hexapeptide] complex
• CAS: 503417-04-7
• 化学式: C₃₂H₄₈CuN₁₂O₁₀
• 分子量: 824.354
• InChiKey: VMRDWPFZKQQUKC-LJQLEUQPSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  Ac-Thr-Glu-Ala-His-His-Lys-NH2 hexapeptide 、 水 、 copper(II) nitrate 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 Cu(2+)*[Ac-Thr-Glu-Ala-His-His-Lys-NH2 hexapeptide] complex 、 Cu(2+)*[Ac-Thr-Glu-Ala-His-His-Lys-NH2 hexapeptide]*H2O complex 、 Cu(2+)*[Ac-Thr-Glu-Ala-His-His-Lys-NH2 hexapeptide]*H2O complex 、 Cu(2+)*[Ac-Thr-Glu-Ala-His-His-Lys-NH2 hexapeptide]*3H2O complex
  参考文献：
  名称：

  Potentiometric and spectroscopic studies of the interaction of Cu(II) ions with the hexapeptides AcThrAlaSerHisHisLysNH2, AcThrGluAlaHisHisLysNH2, AcThrGluSerAlaHisLysNH2 and AcThrGluSerHisAlaLysNH2, models of C-terminal tail of histone H2A

  摘要：

  The hexapeptides AcThrAlaSerHisHisLysNH(2), AcThrGluAlaHisHisLysNH(2), AcThrGluSerAlaHisLysNH(2) and AcThrGluSerHisAlaLysNH(2) which represent modifications of the 120-125 sequence of histone H2A were synthesized and their interactions with Cu(II) ions were studied with potentiometric and spectroscopic (UV-Vis, EPR and CD spectroscopy) studies. All peptides coordinate Cu(II) efficiently. At physiological pH, AcThrAlaSerHisHisLysNH(2) forms dimeric species while the rest of the peptides form monomers. The dimer is formed when Cu(II) ions coordinate equatorially through the imidazole nitrogen of the His-4 residue and the amide nitrogens of the Ser-3 and His-4 residues, plus the imidazole nitrogen of the His-5 residue of a second peptide molecule after deprotonation. At higher pH peptides AcThrAlaSerHisHisLysNH(2) and AcThrGluAlaHisHisLysNH(2) are using the second histidine residue for coordination at the apical position while Cu(II) ions coordinate equatorially with the imidazole nitrogen of His-5 or His-4 and three amido nitrogens with the peptides AcThrGluSerAlaHisLysNH(2) and AcThrGluSerHisAlaLysNH(2) (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(02)00925-8