2-iodo-4-phenylpyrimidine | 53618-63-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-iodo-4-phenylpyrimidine
• 英文别名: 2-Jod-4-phenylpyrimidin
• CAS: 53618-63-6
• 化学式: C₁₀H₇IN₂
• 分子量: 282.083
• InChiKey: HVCSEQGJHGBWJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4-二碘嘧啶 、 苯硼酸 在 sodium carbonate 、 Pd(PPh3)4 作用下， 以 乙醇 、 苯 为溶剂， 反应 54.0h， 以35%的产率得到2-iodo-4-phenylpyrimidine
  参考文献：
  名称：

  Arylation of Halogenated Pyrimidines via a Suzuki Coupling Reaction

  摘要：

  The Suzuki coupling reaction has been used extensively for the synthesis of a wide variety of unsymmetrical biaryl compounds. We have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, it has been shown that chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines.

  DOI：

  10.1021/jo010573+

文献信息

• [EN] NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS<br/>[FR] NOUVEAUX AGONISTES DE RÉCEPTEURS ADRÉNERGIQUES BÊTA 3 DÉRIVÉS DE PYRROLIDINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2011025690A1

  公开（公告）日：2011-03-03

  The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

  本发明提供了化合物的公式（I），其药物组成部分以及使用该化合物在治疗或预防由β3-肾上腺素受体激活介导的疾病中的方法。
• CETP INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1954287B1

  公开（公告）日：2011-11-16
• NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2470021B1

  公开（公告）日：2014-10-22
• ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3489249B1

  公开（公告）日：2021-06-09
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：US20200395560A1

  公开（公告）日：2020-12-17

  Provided are an organometallic compound represented by Formula 1, an organic light-emitting device including the organometallic compound, and a diagnostic composition including the organometallic compound. M 1 (L 11 ) n11 (L 12 ) n12 wherein L 11 in Formula 1 is a ligand represented by Formula 1-1, and the descriptions of other substituents are the same as described in the detailed description of the present application: