8-[(2S,4S)-2,4-dihydroxy-3-oxooxolan-2-yl]octanoic acid | 658680-65-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-[(2S,4S)-2,4-dihydroxy-3-oxooxolan-2-yl]octanoic acid
• CAS: 658680-65-0
• 化学式: C₁₂H₂₀O₆
• 分子量: 260.28
• InChiKey: PZSACNBTWWKKGG-CABZTGNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Cell-free expression system for the detection of bacterial biofilms
  申请人：Freemont Paul

  公开号：US20100021942A1

  公开（公告）日：2010-01-28

  Provided is a cell-free expression system and method for its use for detecting the presence of a bacterial biofilm on a surface, wherein the film comprises a) an exogenous quorum sensing protein or an exogenous nucleic acid sequence coding for a quorum sensing protein capable of selectively binding to a bacterial signaling molecule; and b) an exogenous nucleic acid sequence comprising a promoter operably linked to a nucleic acid sequence coding for a marker protein, wherein the promoter is regulated by the binding of the quorum sensing protein to the bacterial signaling molecule. Further provided is an aerosol formulation, as well as an adhesive bandage, each of which may be used for detecting the presence of a bacterial biofilm on a surface, comprising the disclosed cell free expression system and methods therefor.

  提供了一种无细胞表达系统及其使用方法，用于检测表面上细菌生物膜的存在，其中膜包括a）外源性定量感应蛋白或编码定量感应蛋白的外源性核酸序列，其能够选择性地结合到细菌信号分子；以及b）包括可操作地连接到编码标记蛋白的核酸序列的启动子的外源性核酸序列，其中启动子由定量感应蛋白与细菌信号分子的结合调节。此外，还提供了气雾剂配方以及粘合绷带，每种都可以用于检测表面上的细菌生物膜，包括所述的无细胞表达系统及其方法。
• Methods For The Treatment Of An Infectious Bacterial Disease With An Anti-Lactone Or Lactone Derived Signal Molecules Antibody
  申请人：Charlton Keith Alan

  公开号：US20100303831A1

  公开（公告）日：2010-12-02

  The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognising the native signal molecule(s). By binding to signalling molecules, the receptors reduce and maintain extra-cellular concentrations of signal molecules below the threshold level that would otherwise result in certain opportunistic pathogens adopting a virulent form, and can transform virulent organisms to non-virulent states. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease monitoring and management, and in related applications where the host for infection is an animal or plant.
• Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody
  申请人：Charlton Keith Alan

  公开号：US20130045208A1

  公开（公告）日：2013-02-21

  The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognising the native signal molecule(s). By binding to signalling molecules, the receptors reduce and maintain extra-cellular concentrations of signal molecules below the threshold level that would otherwise result in certain opportunistic pathogens adopting a virulent form, and can transform virulent organisms to non-virulent states. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease monitoring and management, and in related applications where the host for infection is an animal or plant.
• US7812134B2
  申请人：——

  公开号：US7812134B2

  公开（公告）日：2010-10-12
• US8168397B2
  申请人：——

  公开号：US8168397B2

  公开（公告）日：2012-05-01