N-methyl-2-oxo-N,5-diphenylpentanamide | 1335243-11-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-methyl-2-oxo-N,5-diphenylpentanamide
• CAS: 1335243-11-2
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.354
• InChiKey: LFMMVCDOVBZWFU-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  N-methyl-2-oxo-N,5-diphenylpentanamide 在 三氟乙酸 作用下， 以87%的产率得到1-methyl-3',4'-dihydro-2'H-spiro[indoline-3,1'-naphthalen]-2-one
  参考文献：
  名称：

  Trifluoroacetic Acid-Promoted Synthesis of 3-Hydroxy, 3-Amino and Spirooxindoles from α-Keto-N-Anilides

  摘要：

  Ketoanilides containing alkyl side chains were readily cyclized to 3-hydroxy-2-oxindoles or spirooxindoles by a single or double intramolecular Friedel-Crafts reaction in the presence of trifluoroacetic acid (TFA) at room temperature or at 45 degrees C. alpha-Iminocarboxamides, generated in situ from ketoamides, cyclized similarly to 3-aminooxindoles under identical conditions,

  DOI：

  10.1021/ol202263a