2,2-Dimethyl-6-(trifluoromethyl)morpholine | 1478030-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2,2-Dimethyl-6-(trifluoromethyl)morpholine
• CAS: 1478030-16-8
• 化学式: C₇H₁₂F₃NO
• mdl: MFCD21126182
• 分子量: 183.17
• InChiKey: UJMIFBJIOQFGBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors
  申请人：Merck Sharp & Dohme Corp.

  公开号：US11377438B2

  公开（公告）日：2022-07-05

  Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

  结构式（I）的新型化合物及其药学上可接受的盐类是 Nav1.8 通道活性的抑制剂，可用于治疗、预防、管理、改善、控制和抑制由 Nav1.8 通道活性介导的疾病。本发明的化合物可用于治疗、预防或控制疼痛疾病、咳嗽疾病、急性瘙痒疾病和慢性瘙痒疾病。
• INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：ViiV Healthcare UK (No.5) Limited

  公开号：EP3877387A1

  公开（公告）日：2021-09-15
• 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20200140411A1

  公开（公告）日：2020-05-07

  Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na v 1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Na v 1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.