Carbazol-tetrasulfonsaeure-(1,3,6,8) | 103859-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Carbazol-tetrasulfonsaeure-(1,3,6,8)
• 英文别名: carbazole-1,3,6,8-tetrasulfonic acid；Carbazol-1,3,6,8-tetrasulfonsaeure；9H-carbazole-1,3,6,8-tetrasulfonic acid
• CAS: 103859-50-3
• 化学式: C₁₂H₉NO₁₂S₄
• 分子量: 487.467
• InChiKey: LBHWDDOYJFYHTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  267
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• SMALL MOLECULE ANTAGONISTS OF DUSP5 AND METHODS OF USE
  申请人：THE MEDICAL COLLEGE OF WISCONSIN, INC.

  公开号：US20180000778A1

  公开（公告）日：2018-01-04

  The present invention is directed to compounds that specifically target DUSP5 and act as antagonists of that enzyme. Such compounds are useful in the treatment of various conditions including, but not limited to vascular anomalies, cancer, and macular degeneration.
• Inducing Proliferation of Cardiomyocytes and Therapeutic Uses Related Thereto
  申请人：Emory University

  公开号：US20210299078A1

  公开（公告）日：2021-09-30

  This disclosure relates to methods of treating or preventing heart malformations or cardiovascular diseases comprising administering an effective amount of thyroid hormone in combination with i) an agent that decreases DUSPS and/or DUSP6 expression and/or ii) a beta-adrenergic blocking agent to a subject in need thereof. In certain embodiments, this disclosure relates to in vivo and in vitro methods of inducing proliferation of cardiomyocytes using agents or combinations of agents disclosed herein.
• [EN] SMALL MOLECULE ANTAGONISTS OF DUSP5 AND METHODS OF USE<br/>[FR] PETITES MOLÉCULES ANTAGONISTES DE DUSP5 ET PROCÉDÉS D'UTILISATION
  申请人：WISCONSIN MED COLLEGE INC

  公开号：WO2016115460A1

  公开（公告）日：2016-07-21

  The present invention is directed to compounds that specifically target DUSP5 and act as antagonists of that enzyme. Such compounds are useful in the treatment of various conditions including, but not limited to vascular anomalies, cancer, and macular degeneration.