6-Amino-2-(4-chloro-2,3-difluorophenyl)-5-vinyl-pyrimidine-4-carboxylic acid methyl ester | 1136960-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-Amino-2-(4-chloro-2,3-difluorophenyl)-5-vinyl-pyrimidine-4-carboxylic acid methyl ester
• 英文别名: methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-5-ethenylpyrimidine-4-carboxylate
• CAS: 1136960-40-1
• 化学式: C₁₄H₁₀ClF₂N₃O₂
• 分子量: 325.702
• InChiKey: XTGSSICWUIRNLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-(4-chloro-2,3-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 、 methyl 6-amino-2-chloro-5-vinylpyrimidine-4-carboxylate 在 bis-triphenylphosphine-palladium(II) chloride cesium fluoride 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 0.58h， 以36.7%的产率得到6-Amino-2-(4-chloro-2,3-difluorophenyl)-5-vinyl-pyrimidine-4-carboxylic acid methyl ester
  参考文献：
  名称：

  2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES

  摘要：

  在5位上具有烷基、烯基或炔基取代基的6-氨基-4-嘧啶羧酸，以及在3位上具有烷基、烯基或炔基取代基的4-氨基吡啶羧酸，以及它们的胺和酸衍生物，是表现出广谱除草作用的有效除草剂。

  公开号：

  US20090088322A1

文献信息

• 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES
  申请人：Epp Jeffrey B.

  公开号：US20100041556A1

  公开（公告）日：2010-02-18

  6-Amino-4-pyrimidinecarboxylic acids having alkyl, alkenyl or alkynyl substituents in the 5-position and 4-aminopicolinic acids having alkyl, alkenyl or alkynyl substituents in the 3-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

  具有烷基，烯基或炔基取代基的5-位置的6-氨基-4-嘧啶羧酸和具有烷基，烯基或炔基取代基的3-位置的4-氨基吡啶羧酸及其胺和酸衍生物是具有广谱杂草控制作用的强效除草剂。
• 2-substituted-6-amino-5-alkyl, alkenyl or alkynyl-4-pyrimidinecarboxylic acids and 6-substituted-4-amino-3-alkyl, alkenyl or alkynyl picolinic aids and their use as herbicides
  申请人：Dow AgroSciences LLC.

  公开号：US08268753B2

  公开（公告）日：2012-09-18

  6-Amino-4-pyrimidinecarboxylic acids having alkyl, alkenyl or alkynyl substituents in the 5-position and 4-aminopicolinic acids having alkyl, alkenyl or alkynyl substituents in the 3-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

  在5位上具有烷基、烯基或炔基取代基的6-氨基-4-嘧啶羧酸和在3位上具有烷基、烯基或炔基取代基的4-氨基吡啶羧酸及其胺和酸衍生物，是具有广谱除草作用的强效除草剂。
• 2-substituted-6-amino-5-alkyl, alkenyl or alkynyl-4-pyrimidinecarboxylic acids and 6-substituted-4-amino-3- alkyl, alkenyl or alkynyl picolinic acids and their use as herbicides
  申请人：Dow AgroSciences LLC

  公开号：US07786044B2

  公开（公告）日：2010-08-31

  6-Amino-4-pyrimidinecarboxylic acids having alkyl, alkenyl or alkynyl substituents in the 5-position and 4-aminopicolinic acids having alkyl, alkenyl or alkynyl substituents in the 3-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

  在5位上具有烷基，烯基或炔基取代基的6-氨基-4-嘧啶羧酸和在3位上具有烷基，烯基或炔基取代基的4-氨基吡啶羧酸及其胺和酸衍生物是具有广谱杂草控制能力的强效除草剂。
• 2-substituted-6-amino-5-alkyl, alkenyl or alkynyl-4-pyrimidinecarboxylic acids and 6-substituted-4-amino-3-alkyl, alkenyl or alkynyl picolinic acids and their use as herbicides
  申请人：Epp Jeffrey B.

  公开号：US08658791B2

  公开（公告）日：2014-02-25

  6-Amino-4-pyrimidinecarboxylic acids having alkyl, alkenyl or alkynyl substituents in the 5-position and 4-aminopicolinic acids having alkyl, alkenyl or alkynyl substituents in the 3-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

  具有烷基、烯基或炔基取代基的6-氨基-4-嘧啶羧酸在5位和具有烷基、烯基或炔基取代基的4-氨基吡啶羧酸在3位及其胺和酸衍生物是具有广谱除草作用的强效除草剂。
• Substituted 4-amino-picolinic acids and their use as herbicides
  申请人：Dow AgroSciences, LLC

  公开号：EP2327694B1

  公开（公告）日：2013-07-24