2-Methylene-succinic acid bis-(2-hydroxy-ethyl) ester | 28481-52-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Methylene-succinic acid bis-(2-hydroxy-ethyl) ester
• 英文别名: Bis(2-hydroxyethyl) 2-methylidenebutanedioate
• CAS: 28481-52-9
• 化学式: C₉H₁₄O₆
• 分子量: 218.207
• InChiKey: KGDPCYLOLUTZEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• PARABEN DERIVATIVES FOR PRESERVING CELLULOSIC MATERIALS
  申请人：CARLSON William B.

  公开号：US20130004785A1

  公开（公告）日：2013-01-03

  A method of preserving a cellulosic material are provided. The method includes contacting the cellulosic material with a paraben-containing monomer and polymerizing the paraben-containing monomer. Articles including a cellulosic material and at least one polymer which includes paraben moieties are also provided.

  提供了一种保存纤维素材料的方法。该方法包括将纤维素材料与含对羟基苯甲酸酯单体接触，并聚合含有对羟基苯甲酸酯单体的聚合物。还提供了包括纤维素材料和至少一种包含对羟基苯甲酸酯基团的聚合物的制品。
• Shape-retentive hydrogel particle aggregates and their uses
  申请人：——

  公开号：US20040086548A1

  公开（公告）日：2004-05-06

  The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.

  本发明涉及具有以下特征的水凝胶颗粒和聚集体，包括但不限于保持形状、具有弹性、可控的孔径大小和可控的降解速率，使它们适用于广泛的应用，包括但不限于生物活性物质的控制释放、体内医疗器械、组织生长支架和组织替代。
• Use of adsorbent polymer particles in DNA separation
  申请人：——

  公开号：US20030162853A1

  公开（公告）日：2003-08-28

  The invention is directed to fluorinated particles having adsorbent properties for superior performance as the stationary phase for use in chromatographic separations. In particular, the fluorinated surface of such particles of the invention presents unusual and unexpected polarity that is beneficial in performing chromatographic separations such as that used for DNA.

  本发明涉及具有吸附性能的氟化颗粒，用作色谱分离中的固定相，以实现卓越的性能。特别地，本发明中这些颗粒的氟化表面呈现出不寻常和意外的极性，在进行色谱分离（例如用于DNA的分离）时具有益处。
• SHAPE-RETENTIVE HYDROGEL PARTICLE AGGREGATES AND THEIR USES
  申请人：St. John John V.

  公开号：US20080166409A1

  公开（公告）日：2008-07-10

  The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.

  本发明涉及水凝胶颗粒及由其形成的聚集体，其特征包括但不限于形状保持性、弹性、可控孔径和可控降解速率，使它们在各种应用中有用，包括但不限于生物活性物质的控制释放、体内医疗器械、组织生长支架和组织替代。
• HYDROGEL WOUND DRESSING AND BIOMATERIALS FORMED IN SITU AND THEIR USES
  申请人：St. John John

  公开号：US20110123621A1

  公开（公告）日：2011-05-26

  The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

  本发明涉及一种形成保持形状和适应形状的聚集伤口敷料和生物材料的方法，其由凝胶纳米粒子和伤口或体液组成，这些聚集体由非共价键物理力保持在一起，例如，但不限于疏水-亲水相互作用和氢键。该方法包括将凝胶纳米粒子的干粉引入伤口部位，其中纳米粒子吸收一些血液或伤口渗出物，并在现场凝聚成所述的保持形状的聚集敷料。该方法还包括将干纳米粒子粉末引入或涂覆于体内湿润的组织中，以形成所述的保持形状的生物材料。此外，该方法还包括将生物医学剂合并进来，以生产用于各种医疗应用的医用聚集敷料或生物材料。本发明还涉及使用凝胶纳米粒子形成保持形状的聚集体的方法。