2-methylene-8-phenoxyoctanoic acid | 220077-61-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-methylene-8-phenoxyoctanoic acid
• 英文别名: 2-Methylidene-8-phenoxyoctanoic acid
• CAS: 220077-61-2
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: MFXLAEXKGSUXKV-UHFFFAOYSA-N

物化性质

• 沸点：
  424.546±38.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.057±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methylene-8-phenoxyoctanoic acid 在 nitronium tetrafluoborate 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以93.8%的产率得到2-methylene-8-(2,4-dinitrophenoxy)octanoic acid
  参考文献：
  名称：

  Synthesis of 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid: A selective carnitine palmitoyltransferase-1 inhibitor

  摘要：

  Carnitine palmitoyltransferases 1 and 2 (CPT-1 and CPT-2) catalyze the transfer of long chain fatty acids between carnitine and coenzyme A. Unlike CPT-2, CPT-I exists in at least two isoforms with different physical and kinetic properties. Liver and skeletal muscle each contain a different isoform of CPT-1. Cardiac muscle contains both isoforms, and the minor component is identical to the isoform found in the liver. 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid (2) was reported to be a selective inhibitor for the liver isoform of CPT-1. A synthesis of 2 is described here which involves the reaction of diethyl malonate with 1-bromo-6-phenoxyhexane. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00175-8
• 作为产物：
  描述：

  ethyl 2-methylene-8-phenoxyoctanoate 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以88.9%的产率得到2-methylene-8-phenoxyoctanoic acid
  参考文献：
  名称：

  Synthesis of 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid: A selective carnitine palmitoyltransferase-1 inhibitor

  摘要：

  Carnitine palmitoyltransferases 1 and 2 (CPT-1 and CPT-2) catalyze the transfer of long chain fatty acids between carnitine and coenzyme A. Unlike CPT-2, CPT-I exists in at least two isoforms with different physical and kinetic properties. Liver and skeletal muscle each contain a different isoform of CPT-1. Cardiac muscle contains both isoforms, and the minor component is identical to the isoform found in the liver. 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid (2) was reported to be a selective inhibitor for the liver isoform of CPT-1. A synthesis of 2 is described here which involves the reaction of diethyl malonate with 1-bromo-6-phenoxyhexane. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00175-8

文献信息

• Organic-inorganic hybrid composition, optical member and optical device prepared using the same
  申请人：LMS CO., LTD.

  公开号：US10670796B2

  公开（公告）日：2020-06-02

  Disclosed is an organic-inorganic hybrid composition. The organic-inorganic hybrid composition includes a curable resin and inorganic particles dispersed in the curable resin. The inorganic particle has a core-shell structure composed of a core containing titanium and barium, and a shell containing at least one selected from zirconium, aluminum and chromium. According to this organic-inorganic hybrid composition, a liquid-phase refractive index of the composition can be improved, and as a result, luminance and light transmittance can be improved in an optical member using the same.

  公开了一种有机-无机混合组合物。有机-无机杂化组合物包括可固化树脂和分散在可固化树脂中的无机颗粒。无机颗粒具有核壳结构，由含有钛和钡的核以及含有至少一种选自锆、铝和铬的壳组成。根据这种有机-无机杂化组合物，可以提高组合物的液相折射率，从而提高使用该组合物的光学部件的亮度和透光率。
• ORGANIC-INORGANIC HYBRID COMPOSITION, OPTICAL MEMBER AND OPTICAL DEVICE PREPARED USING THE SAME
  申请人：LMS CO., LTD.

  公开号：US20160070053A1

  公开（公告）日：2016-03-10

  Disclosed is an organic-inorganic hybrid composition. The organic-inorganic hybrid composition includes a curable resin and inorganic particles dispersed in the curable resin. The inorganic particle has a core-shell structure composed of a core containing titanium and barium, and a shell containing at least one selected from zirconium, aluminum and chromium. According to this organic-inorganic hybrid composition, a liquid-phase refractive index of the composition can be improved, and as a result, luminance and light transmittance can be improved in an optical member using the same.