methyl 4-[2-(3-cyanopropyl)-1-methylindol-3-yl]benzoate | 1196785-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: methyl 4-[2-(3-cyanopropyl)-1-methylindol-3-yl]benzoate
• CAS: 1196785-97-3
• 化学式: C₂₁H₂₀N₂O₂
• 分子量: 332.402
• InChiKey: RGSACCQQVZVFRR-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  4-碘苯甲酸甲酯 、 6-(2-N,N-dimethylaminophenyl)-5-hexynenitrile 以 乙腈 为溶剂， 反应 0.5h， 以63%的产率得到methyl 4-[2-(3-cyanopropyl)-1-methylindol-3-yl]benzoate
  参考文献：
  名称：

  An efficient, microwave-assisted, one-pot synthesis of indoles under Sonogashira conditions

  摘要：

  A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.07.075